Clinical and Functional Effectiveness Assessment of Personalized Management Programs for Patients With Frailty

All participants underwent comprehensive geriatric assessment (CGA) and cardiopulmonary exercise testing (CPET). After this the participants will undergo geriatric rehabilitation programs. The participation duration will not exceed 6.5 months including the screening period.

The study comprises three periods:

• screening (1-14 days)
• a treatment course of 3-5 days
• a follow-up period of 6 months On screening visit Study procedures will include
• Informed consent signing
• The Comprehensive Geriatric Assessment (CGA)
• Cardiopulmonary exersize test (CPET)
• The recommendations on a program of geriatric rehabilitation based on CGA and CPET

The inpatient phase will last 3-5 days and will include:

• Implementation of the comprehensive personalized management program
• Issuance of recommendations for continuing the program at the outpatient stage Patients will be randomized into active follow-up and passive follow-up groups based on the number of scheduled telephone contacts using a specially designed structured questionnaire. Active follow-up group: short version of the telephone contact every 1 month during the first three months, with the full version at 3 months. Passive follow-up group: full version of the telephone contact at 3 months. The total duration of the outpatient follow-up phase will be 6 months.

Final visit will be performed at the end of rehabilitation program. It will include:

• The CGA and CPET
• The evaluation of the results of 6 months geriatric rehabilitation program
• The recommendations on a long-term geriatric rehabilitation

Inclusion criteria

• Men and women aged 60 and older who wanted to participate in the study and signed a consent form.

Exclusion criteria

• Presence of acute diseases or exacerbation of chronic diseases within 2 weeks prior to study inclusion.
• Presence of active malignant oncological diseases.
• Presence of severe cognitive impairment (dementia) and sensory deficits that may affect the ability to perform or evaluate study procedures.
• Presence of anemia (hemoglobin level <110 g/L).
• Presence of musculoskeletal disorders or peripheral artery disease that may affect mobility and the ability to undergo study procedures.
• Presence of one or more contraindications to exercise testing.
• Any other condition that, in the investigator's opinion, may preclude the patient's participation in the study.