Skip to main content
OpenTrials
Completed

NCT Number: NCT03115775

CLA and Vitamin D on Protein Turnover

To conduct a randomized, double-blind, controlled clinical trial to determine the independent and combined effects of dietary conjugated linoleic acid (CLA) and vitamin D supplementation on anabolic signaling, the expression of growth regulatory factors, and muscle protein turnover in older adults.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Protein

Age range

65 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Washington University

St Louis, Missouri, 63110, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI >/= 18.5 and </= 35.0
  • Serum 25OH-VitD3 < 35 ng/ml

Exclusion criteria

  • Diabetes
  • COPD

Treatment and study plan

Conjugated linoleic acid

Dietary Supplement

Intervention will last up to 8 weeks. Subjects will receive conjugated linoleic acid (4000 mg Tonalin FFA 80) daily.

Other names: Tonalin

Vitamin D

Dietary Supplement

Intervention will last up to 8 weeks. Subjects will receive vitamin D3 (2000 IU) daily.

Conjugated linoleic acid and Vitamin D

Dietary Supplement

Intervention will last up to 8 weeks. Subjects will receive conjugated linoleic acid (4000 mg Tonalin FFA 80) and vitamin D3 (2000 IU) daily.

Corn oil (placebo)

Other

Intervention will last up to 8 weeks. Subjects will receive corn oil (4000 mg) daily.

Primary outcomes

  1. Change in post-absorptive muscle protein synthesis

    Time frame: Baseline and 8 weeks

    A stable isotope labelled amino acid infusion, in conjunction with blood and muscle tissue sampling and mathematical modelling analysis will be used to measure post-absorptive muscle protein synthesis.

  2. Change in combined amino acid and insulin stimulated muscle protein synthesis

    Time frame: Baseline and 8 weeks

    A stable isotope labelled amino acid infusion, in conjunction with insulin and mixed amino acid infusion, blood and muscle tissue sampling and mathematical modelling analysis will be used to measure muscle protein synthesis.

Sponsors and collaborators

Lead sponsor

Washington University School of Medicine

Other

Collaborators

  • BASF

Registry information

Official study title

Randomized Controlled Trial to Evaluate the Independent and Combined Effects of Conjugated Linoleic Acids and Vitamin D on Muscle Protein Turnover in Older Adults

Acronym: TM

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Apr 14, 2017
Registry last updated
Nov 21, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.