Skip to main content
OpenTrials
Completed

NCT Number: NCT01567176

Circulating SIRT6 Expression, Effect on Aging Quality

This study follows the results of the COMPALICLAMP study (NCT00951392) where the investigators showed a differential expression of sirtuins protein isoforms, Sirt6, in muscle depending on the quality of aging. The investigators seek to confirm this difference in expression level of circulating leukocytes on a larger sample.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Aging Metabolic Diseases Nutritional and Metabolic Diseases

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre de Recherche en Nutrition Humaine, Pierre-Bénite, France

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Volunteers from the SUVIMAX 2 aging cohort
  • Men and women
  • Older than 60
  • Subject with a global aging quality score of 1 or 3 in the SU.VI.MAX. 2 study
  • Covered by Health Insurance System

Exclusion criteria

  • Subject not in compliance with the recommendation of French National Law

Treatment and study plan

Blood sample

Biological

It is a single cross sectional study. All outcome measures will be taken during the investigation with physical examination, questionnaire and a blood sample

Primary outcomes

  1. Sirt6 expression in circulating leukocytes based on the aging quality

    Time frame: participants will be followed for the duration of the visit, an expected average of 1 day

    analysis by quantitative RT-PCR method

Secondary outcomes

  1. hand and forearm muscular strength measurement

    Time frame: participants will be followed for the duration of the visit, an expected average of 1 day

    Hand Grip strength test

  2. Physical examination and anthropometric measurement

    Time frame: participants will be followed for the duration of the visit, an expected average of 1 day

    Measurement of the weight, height, waist, hips, blood pressure, pulse.

  3. Cognitive assessment

    Time frame: participants will be followed for the duration of the visit, an expected average of 1 day

    MMSE (Mini Mental State Examination), Five-word test, clock drawing

  4. Physical Activity questionnaire

    Time frame: participants will be followed for the duration of the visit, an expected average of 1 day

    MAQ (Modifiable Activity Questionnaire)

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Circulating Expression Measurement of a Sirtuin Protein Isoform, Sirt6, as an Early Marker of Aging Quality

Acronym: Sirt6

Important dates

Study start
2012
Primary completion
2012
Study completion
2012
First posted
Mar 30, 2012
Registry last updated
May 28, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.