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Completed

NCT Number: NCT05110872

Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace

This is a one-session study that participants complete remotely including consent, Experimental Tobacco Marketplace purchases, and assessments to examine the effects of cigarette and e-cigarette flavors on cigarette demand and substitution in the Experimental Tobacco Marketplace.

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Key information

Conditions

Tobacco Use Disorder Behavior Chemically-Induced Disorders Mental Disorders Smoking Substance-Related Disorders Vaping

Age range

21 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Fralin Biomedical Research Institute

Roanoke, Virginia, 24016, United States

About this study

This study uses a mixed design (within-subject repeated measures and between-group). Participants will be assigned to two different groups according to their preferred cigarette flavor (tobacco/menthol). Every participant will complete behavioral tasks and make hypothetical purchases of tobacco products in an online store under four different scenarios: a) e-cigarette flavor restricted and cigarette flavor restricted, b) e-cigarette flavor unrestricted and cigarette flavor restricted, c) e-cigarette flavor restricted and cigarette flavor unrestricted, d) e-cigarette flavor unrestricted and cigarette flavor unrestricted.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • currently smoke at least 10 cigarettes per day
  • have smoked at least 100 cigarettes (lifetime), and
  • are 21 years of age or older.

Exclusion criteria

  • inaccurate identification of usual brand of cigarette's as menthol or non-menthol

Treatment and study plan

Cigarette flavor restricted and e-cigarette flavor restricted

Behavioral
  • Tobacco cigarettes will be available in the Experimental Tobacco Marketplace
  • Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace

Cigarette flavor restricted and e-cigarette flavor unrestricted

Behavioral
  • Tobacco cigarettes will be available in the Experimental Tobacco Marketplace
  • Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace

Cigarette flavor unrestricted and e-cigarette flavor restricted

Behavioral
  • Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace
  • Tobacco-flavored e-cigarettes will be available in the Experimental Tobacco Marketplace

Cigarette flavor unrestricted and e-cigarette flavor unrestricted

Behavioral
  • Tobacco and menthol cigarettes will be available in the Experimental Tobacco Marketplace
  • Tobacco-flavored and a range of flavored e-cigarettes will be available in the Experimental Tobacco Marketplace

Primary outcomes

  1. Spent the Budget on E-cigarettes for Each Condition

    Time frame: 1 day

    Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Product availability in the ETM depended on the experimental condition. The average percentage of budget spent on e-cigarettes as a function of the restriction of cigarettes and/or e-cigarettes will be assessed.

  2. Spent Budget on Cigarettes for Each Condition

    Time frame: 1 day

    Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Product availability in the ETM depended on the experimental condition. The average percentage of the budget spent on cigarettes as a function of the restriction of cigarettes and/or e-cigarettes will be assessed.

Sponsors and collaborators

Lead sponsor

Virginia Polytechnic Institute and State University

Other

Collaborators

  • National Cancer Institute (NCI)
  • University of Minnesota

Registry information

Official study title

COMET Study 2: Effects of Cigarette and E-cigarette Flavor Restrictions on Cigarette Demand and Substitution in the Experimental Tobacco Marketplace

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Nov 8, 2021
Registry last updated
Oct 7, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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