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OpenTrials
Completed

NCT Number: NCT02697695

Chronic Inflammation After Obesity Surgery

To evaluate the impact of obesity surgery on chronic inflammation.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

About this study

A retrospective study to compare the impact of laparoscopic sleeve gastrectomy (LSG), laparoscopic Roux-en Y- gastric bypass (LRYGB) and laparoscopic omega-loop gastric bypass (LOLGB) on chronic inflammation and metabolic syndrome.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI > 35kg/m² and obesity-related disease or BMI > 40kg/m²

Exclusion criteria

  • acute inflammation during laboratory examination

Treatment and study plan

Laboratory Examination

Other

Laboratory Examination before, 1 month, 3 month, 6 month and up to 12 month after LSK, LRNYGB, LOLGB

Primary outcomes

  1. Chronic inflammation

    Time frame: one day preoperatively, and 1 month, 3 month, 6 month and up to 12 month postoperatively

    the changing of leucocytes in /nl after obesity surgery

Secondary outcomes

  1. Fatty liver index

    Time frame: one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively

    the changing of fatty liver index after obesity surgery

  2. Liver enzymes

    Time frame: one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively

    the changing of GOT in U/l, GPT in U/l, GGT in U/l, AP in U/l after obesity surgery

  3. Body Mass Index (BMI) in kg/m²

    Time frame: one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively

    the changing of BMI in kg/m² before and after obesity surgery

  4. weight in kg

    Time frame: one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively

    the changing of weight before and after obesity surgery

  5. waist circumference

    Time frame: one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively

    the changing of waist circumference in cm before and after obesity surgery

  6. HbA1c

    Time frame: one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively

    the changing of HbA1c in % and after obesity surgery

  7. Chronic inflammation II

    Time frame: one day preoperatively and 1 month, 3 month, 6 month and up to 12 month postoperatively

    the changing of c-reactive protein in mg/l after obesity surgery

  8. Acute inflammation

    Time frame: one day preoperatively and one and four days postoperatively

    the changing of c-reactive protein in mg/l after obesity surgery

  9. Acute inflammation II

    Time frame: one day preoperatively and one and four days postoperatively

    the changing of leucocytes in /nl after obesity surgery

Sponsors and collaborators

Lead sponsor

Sana Klinikum Offenbach

Other

Registry information

Official study title

Impact of Obesity and Metabolic Surgery on Chronic Inflammation

Important dates

Study start
2014
Primary completion
2015
Study completion
2016
First posted
Mar 3, 2016
Registry last updated
Jul 31, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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