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OpenTrials
Completed

NCT Number: NCT03850548

Chronic Infections on Articular Prostheses With C. Acnes Diagnosed by Specific PCR

Osteaoarticular infection due to C. acnes are known to be of late onset, causing chronic infection possibly pauci-symptomatic. Osteaoarticular infection due to C. acnes represents a diagnostic challenge, since C. acnes is slow and difficult to grow, and can also be considered a contaminant.A 16S universal PCR bacteriological diagnosis has been proposed but is lacking of sensitivity. A specific C. acnes PCR was developed in 2010, but is not used routinely.

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Key information

Conditions

Bone and Joint Infection

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospices Civils de Lyon

Lyon, 69004, France

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients having had infection prothesis vith C. acnes identified by PCR

Exclusion criteria

  • none

Treatment and study plan

Prosthetic joint infection with Cutibacterium acnes

Other

patients having a prosthesis infection with C.acnes identified by specific PCR

Primary outcomes

  1. Rate of diagnostic delay

    Time frame: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption

    time between surgery and detection of C. acnes by PCR

Secondary outcomes

  1. rate of radiologic signs

    Time frame: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption

    prosthesis loosening or not

  2. rate of duration of antibiotherapy

    Time frame: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption

    measures of duration of the antibiotherapy

  3. rate of use of this diagnostic

    Time frame: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption

    descriptions of patients managed with this diagnostic

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Chronic Infections on Articular Prostheses With C. Acnes Diagnosed by Specific PCR : Descriptive Study of 6 Patients

Important dates

Study start
2016
Primary completion
2017
Study completion
2018
First posted
Feb 22, 2019
Registry last updated
Feb 22, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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