Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections

Different mechanisms have been proposed to explain the pathophysiology of chronic staphylococcal BJI, including biofilm formation and the ability of staphylococci to be internalized and to survive within cells. The intracellular localization of staphylococci is well documented by in vitro studies, however, few studies have shown the presence of intracellular staphylococci in clinical specimens from patients with BJI.

The aim of the CRISBO study is to document the clinical relevance of intracellular staphylococci in the context of BJI. Immunostaining targeting staphylococci and components will be carried out on tissue samples taken from patients with BJI during their treatment (samples similar to those used for routine diagnosis in pathology). Our objectives are to identify whether intracellular staphylococci are observable in these samples and if so, in which cell type (s) are they housed.

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Key information

Conditions

Bone and Joint Infection Staphylococcus

Age range

18 year–95 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospices Civils de Lyon

Lyon, 69004, France

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients having had an osteo-articular infection with Staphylococci

Exclusion criteria

Treatment and study plan

Patients having had an osteo-articular infection with Stahylococcus

Other

Immunostaining targeting staphylococci and components will be performed on tissue samples collected from patients with osteo-articular infection

Primary outcomes

detection of intracellular staphylococci

Time frame: 2 months

to explore if intracellular staphylococci can be observed on samples of patient having an osteo-articular infection with staphylococci
rate of localisation of intracellular staphylococci

Time frame: 2 months

to explore where in what type of celles they can be observed on samples of patient having an osteo-articular infection with staphylococci

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Acronym: CRISBO

Important dates

Study start: 2020
Primary completion: 2021
Study completion: 2021
First posted: Nov 12, 2020
Registry last updated: Dec 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed