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OpenTrials
Completed

NCT Number: NCT05227248

Chocolate Dynamic Vessel Analysis

The study aims at evaluating the effect of dark chocolate consumption on anatomy and functionality of retinal blood vessels by comparing these same parameters after milk chocolate consumption.

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Key information

Conditions

Retinal Vascular

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Giuseppe Querques

Milan, 20134, Italy

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age of 18 years or older
  • Healthy volunteers
  • No vascular diseases
  • No ocular diseases
  • Volunteers capable of understanding informed consent

Exclusion criteria

  • Patient unable to follow the instructions
  • Patient unable to come back for follow-up
  • opacity of lens, cornea, or vitreous
  • Allergies that contraindicate pupil dilation
  • Eye diseases
  • Myopia greater than -8.0 Diopter (D),
  • Hyperopia greater than 5.0 D
  • Astigmatism greater than -3.0 D

Treatment and study plan

Dark chocolate

Dietary Supplement

Patients were administered 20 grams of dark chocolate

Milk Chocolate

Dietary Supplement

Patients were administered 7.5 grams of milk chocolate

Primary outcomes

  1. Retinal perfusion

    Time frame: Baseline, 2 hours after intervention

    Changes in retinal perfusion using Optical Coherence Tomography Angiography

  2. Retinal vascular response

    Time frame: Baseline, 2 hours after intervention

    Changes in retinal vascular response to flicker stimulation using Dynamic Vessels Analysis and Retinal Vessels Analysis

Secondary outcomes

  1. Visual Acuity

    Time frame: Baseline, 2 hours after intervention

    Best Corrected Visual Acuity changes

Sponsors and collaborators

Lead sponsor

Querques Giuseppe

Other

Registry information

Official study title

Evaluation of the Effects of Chocolate on Anatomy and Functionality of Retinal Blood Vessels

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Feb 7, 2022
Registry last updated
Mar 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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