Chart Review: Central Motor Conduction Time in Neurological Disorders

Background:

TMS stands for transcranial magnetic stimulation. It is a non-invasive way to stimulate the brain. It helps researchers study the nervous system. TMS can assess central motor conduction time (CMCT). That can be used to diagnose some diseases. It can also show how well treatments are working. Researchers want to study the records of people who have already had TMS. They want to see how it relates to the results of diagnostic studies.

Objectives:

To study the results of transcranial magnetic stimulation in certain neurological disorders. To create a descriptive analysis of the results.

Eligibility:

Records that are already in the NINDS database

Design:

The study will not enroll any participants.

Researchers will search the database for certain terms. These include TMS, CMTC, and motor evoked potentials. This will identify records of people who had TMS for diagnosis.

Using data from the records, researchers will calculate CMCT. They will note other data that relate to CMCT.

Researchers will analyze their findings. They will write a review article.

Personal data will be removed from all the records before the findings are analyzed.

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Key information

Conditions

Neurological Disorder Nervous System Diseases

Age range

18 year–130 year

Sex eligibility

All sexes

Study type

Observational

Primary location

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, 20892, United States

About this study

Objective- To retrospectively study the results of transcranial magnetic stimulation (TMS) in various neurological disorders and create a descriptive analysis of the results.

Study population- Existing records of patients within the NINDS database who have had TMS performed to measure central motor conduction time (CMCT).

Design-

Retrospective descriptive analysis.
The NINDS EMG Database will be queried using terms such as TMS, CMCT, and MEP (motor evoked potentials) to identify EMG reports on patients who underwent TMS for diagnosis
Within these reports peripheral motor conduction time (PMCT), the cortical motor evoked potential (MEP) latency and amplitude will be used to calculate CMCT, clinical patient factors pertinent to estimation of CMCT as well clinically significant physical exam findings will be recorded as well.
Clinical diagnoses and neurological exams will be extracted from medical records
Patient identifiers will be de-linked after compiling data from medical records

Outcome measures

Results of CMCT using TMS in different diagnoses will be summarized for different neurologic disorders and correlated to clinical exam measures documented in previous records

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

INCLUSION CRITERIA:

Patients who were seen in the NINDS EMG section for diagnostic TMS studies
Patients tested between 1998 and 2017
Greater than or equal to age 18.

Treatment and study plan

Primary outcomes

Summary of central motor conduction studies in neurological disorders

Time frame: Study completion

Sponsors and collaborators

Lead sponsor

National Institute of Neurological Disorders and Stroke (NINDS)

Nih

Registry information

Important dates

Study start: 2017
Primary completion: 2018
Study completion: 2018
First posted: Oct 4, 2017
Registry last updated: Aug 1, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed