Characterization of Low Density Lipoprotein and Mechanism of the Pro Aggregant Effect Through Oxidant Stress and Lipid Exchange

Case control design: lipidomic study in 12 type 2 diabetics with metabolic syndrome, 12 metabolic syndrome without diabetes, 12 subjects with type 1 diabetes and 12 controls

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Key information

Conditions

Diabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Metabolic Syndrome Nutritional and Metabolic Diseases

Age range

30 year–75 year

Sex eligibility

Male

Study type

Observational

Primary location

Fédération d'Endocrinologie-Diabétologie-Maladies métaboliques-Nutrition - Hôpital Cardiovasculaire et Pneumologique

Lyon, 69394, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

statin and fibrate Wash out for one week
HbA1c>7% and <12% (Arms 1 and 3)
HbA1c<6% (Arms 2 and 4)
Metabolic sd according NCEP III (3 out 4 criteria) (Arms 1 and 2)

Exclusion criteria

secondary CV prevention

Treatment and study plan

Blood sample

Procedure

Blood sample for lipidomic study

Primary outcomes

Level of plasma isoprostane and lipoperoxides

Time frame: at baseline

Secondary outcomes

TXA2 and PF4 levels after platelet activation of control platelet exposed to LDL

Time frame: 2 hours

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Acronym: ECLIPSE

Important dates

Study start: 2009
Primary completion: 2010
Study completion: 2010
First posted: Jul 2, 2009
Registry last updated: Apr 13, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed