Characterization and Differential Diagnosis of Vertebral Osteomyelitis

Vertebral osteomyelitis is a uncommon disease that can lead to neurologic deficits if not diagnosed in time. The etiologies of vertebral osteomyelitis include pyogenic bacteria, M. tuberculosis, Brucella species, and fungus. The aim of this study is to describe the clinical features and microbiological/radiological characteristics of patients with vertebral osteomyelitis, and investigate the useful tips for the differential diagnosis of vertebral osteomyelitis.

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Key information

Conditions

Vertebral Osteomyelitis Bone Diseases Bone Diseases, Infectious Infections Musculoskeletal Diseases Osteomyelitis

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Asan Medical Center

Seoul, 138-736, South Korea

About this study

Besides description of characteristics of patients with vertebral osteomyelitis, we also will investigate the usefulness of 16S rRNA gene sequence analysis of biopsy specimen. MRI findings during the antibiotic treatment will be monitored and compared for the differential diagnosis of meningitis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Symptoms or signs consistent with spinal column infection
MRI findings suggestive of infection
Antibiotic treatment for vertebral myelitis

Exclusion criteria

Patients already treated more than 2 weeks for osteomyelitis in transferring hospital

Treatment and study plan

Primary outcomes

Identification of etiology of vertebral osteomyelitis

Time frame: within 6 weeks after the diagnosis of vertebral osteomyelitis

Secondary outcomes

Unfavorable outcomes (death or permanent neurologic deficit)

Time frame: within 6 months after the diagnosis of vertebral osteomyelitis

Sponsors and collaborators

Lead sponsor

Asan Medical Center

Other

Registry information

Official study title

Clinical Features, Microbiological-, Radiological Characteristics, and Differential Diagnosis of Vertebral Osteomyelitis

Important dates

Study start: 2010
Primary completion: 2013
Study completion: 2013
First posted: May 19, 2010
Registry last updated: Feb 25, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed