Characteristics of Infective Endocarditis in East China

This was a retrospective observational study of consecutive cases of definite or possible infective endocarditis (IE) as per the modified Duke criteria between January 2008 and December 2015, which was performed at the Second Affiliated Hospital of Zhejiang University, School of medicine (SAHZU), a tertiary care referral hospital located in East China.

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Key information

Conditions

Infective Endocarditis Cardiovascular Diseases Endocarditis Heart Diseases

Sex eligibility

All sexes

Study type

Observational

About this study

Infective endocarditis (IE) is a rare but life-threatening serious disease that still has a high mortality, even in developed countries. The objective of this study was to evaluate the clinical presentations, treatment and outcomes of IE patients in a tertiary hospital in East China over an 8-year period. This was a retrospective observational study of consecutive cases of definite or possible IE as per the modified Duke criteria between January 2008 and December 2015.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with a clinical diagnosis of infective endocarditis.

Exclusion criteria

Patients did not meet the modified Duke criteria.

Treatment and study plan

No intervention

Other

no intervention

Primary outcomes

Complications (neurological events, systemic embolism, and congestive heart failure) of infective endocarditis

Time frame: During the hospitalization, average of 1 months
- A neurological event was defined as symptomatic or asymptomatic stroke, hemorrhage, or encephalopathy.
- Systemic embolization was defined as an embolic event outside of the central nervous system.
- Congestive heart failure was defined as with class III, or IV heart failure and an ejection fraction of 40% or less.
Mortality

Time frame: During the hospitalization, average of 1 months

Patients dead or moribund before discharge

Sponsors and collaborators

Lead sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Other

Registry information

Official study title

Study of the Clinical Presentations, Treatment and Outcomes of Infective Endocarditis Patients in a Tertiary Hospital in East China

Important dates

Study start: 2008
Primary completion: 2015
Study completion: 2016
First posted: Jul 27, 2021
Registry last updated: Jul 27, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed