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NCT Number: NCT06994208

Characteristics of Adult Patients With Melanoma Diagnosis <40 Years Age.

The primary objective of the study is to analyse a local cohort of patients aged 18-39 years with melanoma diagnosis in order to determine the prevalence of the disease in this age group.

Secondary objectives are the following:

* To identify risk factors associated with melanoma in young people. * To characterise the phenotype and dermoscopic features of melanoma in patients aged 18-39 years. * To analyse the relationship between the clinical and histopathological features of melanoma in young people. * To identify the mutational status of B-RAF in the sample of patients analysed.

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Key information

Conditions

Melanoma of Skin Melanoma Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Germ Cell and Embryonal Neoplasms, Nerve Tissue Neuroectodermal Tumors Neuroendocrine Tumors Nevi and Melanomas Skin Diseases Skin Neoplasms Skin and Connective Tissue Diseases

Age range

18 year–39 year

Sex eligibility

All sexes

Study type

Observational

Primary location

E.O. Ospedali Galliera

Genoa, Liguria, 16128, Italy

Location status: Recruiting

Location contact

Sanja Javor, MD

CONTACT

[email protected]

+390105634278

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • written informed consent
  • age > 18 years and < 40 years
  • diagnosis of cutaneous melanoma even non-primary

Exclusion criteria

-

Treatment and study plan

Primary outcomes

  1. Melanoma prevalence

    Time frame: 3 years

    Estimated prevalence of melanoma in a cohort group of patients aged 18 - 39 years

Secondary outcomes

  1. Risk factor

    Time frame: 3 years

    Identification of risk factors associated with melanoma in young people.

  2. Melanoma phenotype

    Time frame: 3 years

    Description of the main phenotypic of melanoma in this age group.

  3. Histopathological feature

    Time frame: 3 years

    Evaluation of the likely association between clinical and histopathological features of melanoma in young people.

  4. Mutational status

    Time frame: 3 years

    Identification of the presence of B-RAF mutations

  5. Dermoscopy of melanoma

    Time frame: 3 years

    Description of the main dermoscopic characteristics of melanoma in this age group.

Study contacts

Contact information is provided by the study sponsor or research team.

Davide Corradengo

CONTACT

[email protected]

+39010.563.4580

Sanja Javor, MD

CONTACT

[email protected]

+390105634271

Sponsors and collaborators

Lead sponsor

Ente Ospedaliero Ospedali Galliera

Other

Registry information

Official study title

Demographic, Clinical, Dermoscopic, Phenotypic and Genetic Characteristics of Adult Patients With Melanoma Diagnosis <40 Years Age. A Prospective, Monocentric Observational Study

Acronym: MELA_2025

Important dates

Study start
2025
Primary completion
2027
Study completion
2028
First posted
May 29, 2025
Registry last updated
Dec 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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