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Completed

NCT Number: NCT01512368

Changes in Serum Fibroblast Growth Factor 21 (FGF21) Levels Correlated With Exercise

We evaluated the effect of two weeks of intensive supervised physical activity in serum fibroblast growth factor 21 (FGF21) levels.

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Key information

Conditions

Sedentary Lifestyle Behavior Motor Activity Sedentary Behavior

Age range

18 year–35 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

INCMNSZ

Mexico City, Tlalpan, 14000, Mexico

About this study

Comparative and longitudinal study. Anthropometric and biochemical evaluation were done before, 1hr and 4hr after a bout of exercise and repeated after two weeks of daily supervised exercise. We studied sedentary young healthy women. A treadmill exercise test (following the Bruce's protocol) was done five times per week (from Monday to Friday) for two weeks. The Department of Endocrinology and Metabolism at the INCMNSZ performed all biochemical laboratory measurements using standardized procedures.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women
  • Aged 18 to 35 years old,
  • Body mass index (BMI) <30 kg/m2
  • Without contraindication for exercising

Exclusion criteria

  • Metabolic syndrome
  • Diabetes
  • Dyslipidemia
  • Hypertension
  • Asthma
  • Thyroid disease
  • Treated with fibrates, beta agonists or blockers
  • History or current arrhythmias, murmurs, cardiomegaly, or treatment for cardiovascular diseases -
  • Contraindications for exercise testing were also considered as exclusion criteria (see references)

Treatment and study plan

Supervised Exercising

Other

A treadmill exercise test (following the Bruce's protocol) was done five times per week (from Monday to Friday) for two weeks.

Other names: Bruce's protocol

Primary outcomes

  1. Change From Baseline Fibroblast Growth Factor 21 (FGF21) Acutely and at Two Weeks

    Time frame: Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise

    Serum measurement of FGF21 using human ELISA kit was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise.

Secondary outcomes

  1. Change From Baseline Free Fatty Acids (FFAs) Acutely and at Two Weeks

    Time frame: Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise

    Serum measurement of free fatty acids (FFAs) was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise.

  2. Change From Baseline Epinephrine Acutely and at Two Weeks

    Time frame: Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise

    Serum measurement of epinephrine was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise.

  3. Change From Baseline Leptin Acutely and at Two Weeks

    Time frame: Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise

    Serum measurement of leptin was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise

  4. Change From Baseline Total Adiponectin Acutely and at Two Weeks

    Time frame: Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise

    Serum measurement of total adiponectin was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise

  5. Change From Baseline Fasting Glucose Acutely and at Two Weeks

    Time frame: Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise

    Serum measurement of glucose was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise

Sponsors and collaborators

Lead sponsor

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Other

Registry information

Official study title

Changes in Serum Fibroblast Growth Factor 21 (FGF21) Levels After a Cardiorespiratory Exercise Program

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Jan 19, 2012
Registry last updated
Jan 14, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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