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OpenTrials
Completed

NCT Number: NCT05618756

CBD, Nutrient Metabolism and Energy Intake

CBD may affect metabolic control and energy intake. However, there is currently little data regarding these specific outcomes in humans. Therefore, this study will investigate whether a single 300 mg dose of CBD can improve metabolic control following a meal and/or reduce energy intake at a subsequent meal. Healthy, adult volunteers will complete two conditions in a crossover design, comparing outcomes following both CBD and placebo supplementation.

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Key information

Conditions

Glucose Metabolism Disorders (Including Diabetes Mellitus) Appetitive Behavior Behavior Behavior, Animal Glucose Metabolism Disorders Lipid Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Loughborough University

Loughborough, Leicestershire, LE11 3TU, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Self-report as healthy, male or female, aged 18-50, body mass index ≥18.5 and <30.0

Exclusion criteria

  • Currently engage in >10 hours moderate or vigorous intensity physical activity per week
  • Have consumed CBD or cannabis at all within the past two months
  • Have used CBD or cannabis regularly (>2x in a week) within the past four months
  • Are suffering from any clinically significant illness
  • Have regularly used tobacco within the previous 6 months (> 2/week)
  • Currently use any prescription or over-the-counter medications (except for hormonal contraception and simple painkillers)
  • Have given a standard blood donation within 30 days of screening
  • Are currently pregnant or lactating
  • Are allergic/intolerant to any ingredients in food items provided during the study

Treatment and study plan

Acute oral CBD supplementation

Dietary Supplement

1 ml hemp oil containing 300 mg CBD, within gelatin capsules, ingested orally.

Acute oral placebo supplementation

Dietary Supplement

1 ml hemp oil containing no CBD, within gelatin capsules, ingested orally.

Primary outcomes

  1. Energy intake

    Time frame: ~5-30 minutes (time taken to eat a single meal)

    Self-selected energy intake at an ad libitum mixed meal

  2. Postprandial Glycaemia

    Time frame: 3 hours

    Plasma glucose response to a mixed meal (plasma glucose concentrations and area under curve)

  3. Postprandial Triglyceridaemia

    Time frame: 3 hours

    Plasma triglyceride response to a mixed meal (plasma triglyceride concentrations and area under curve)

Secondary outcomes

  1. Postprandial Insulinaemia

    Time frame: 3 hours

    Plasma Insulin response to a mixed meal (plasma insulin concentrations and area under curve)

Sponsors and collaborators

Lead sponsor

Loughborough University

Other

Registry information

Official study title

Effects of Acute Cannabidiol (CBD) Supplementation on Nutrient Metabolism and Energy Intake in Healthy Adults

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Nov 16, 2022
Registry last updated
Feb 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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