Caustic Esophageal Burns in Children and High Doses of Methylprednisolone

Corrosive substance ingestion in childhood is a public health issue in developing countries and several management protocols were proposed to prevent esophageal strictures. The role of corticosteroids in preventing corrosive-induced strictures is controversial. The investigators' aim is to study the influence of high doses of corticosteroids to prevent esophageal strictures.

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Key information

Conditions

Esophageal Diseases Constriction, Pathologic Digestive System Diseases Gastrointestinal Diseases Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms

Age range

12 month–17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-Corrosive substance ingested children with grade IIb esophageal burn

Exclusion criteria

Caustic substance ingested chldren grade I, IIa and grade III esophageal burns
Caustic subtance ingested children with signs of perforation, mediastinitis, peritonitis, sespis
Caustic substance ingested children with any chronic disease

Treatment and study plan

methylprednisolon

Drug

Primary outcomes

Evaluation of stricture development in children with caustic esophageal burns after high doses of methylprednisolone

Time frame: three years

stricture development was evaluated with endoscopic examination and upper gastrointestinal system series with barium swallow

Sponsors and collaborators

Lead sponsor

Sisli Hamidiye Etfal Training and Research Hospital

Other

Registry information

Official study title

High Doses of Methylprednisolone in the Management of Caustic Esophageal Burns in Children

Important dates

Study start: 2007
Primary completion: 2008
Study completion: 2008
First posted: Dec 5, 2013
Registry last updated: Dec 5, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed