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Active, Not Recruiting

NCT Number: NCT07092800

Care Pathways and Disparities in Care for Older Patients With Cancer: Typology, Determinants and Effect on Prognosis ( PASSAGE )

More than half of new cases of cancer in Europe in 2022 occurred in people aged over 70. In addition to cancer, the majority of older people have one or more illnesses that may interact with the treatment decision, cancer progression, tolerance and efficacy of treatments, quality of life, care pathway and survival. Furthermore, cancer treatments are most often evaluated in middle-aged subjects without severe disease, so the real-life management of older patients is often empirical.

The general objective of the PASSAGE project is to assess the hospital care pathways of older patients with cancer treated at AP-HP by evaluating key elements of these pathways from both geriatric and therapeutic perspectives. Characterizing these care trajectories will help identify the most vulnerable patient profiles and potential disparities in access to care, with the goal of optimizing the management of elderly patients with cancer.

The aims of this research are 1) to provide a better description of trends in the management of older cancer patients in routine clinical practice, and 2) to assess the impact of frailty, multimorbidity and the management of these patients on the prognosis of the disease.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Tumor Aged Cancer Causality Frailty Geriatric Assessment Health Services Research Neoplasms Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

70 year–130 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Henri Mondor Hospital

Créteil, VAL DE Marne, 94010, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 70 or over,
  • Having at least one International Classification of Disease, 10th revision (ICD-10) for solid cancer recorded as principal diagnostic or related,
  • During treatment in an AP-HP hospital,
  • Between 01/08/2017 and 31/07/2023.

Exclusion criteria

  • opposition to the reuse of healthcare data

Treatment and study plan

Primary outcomes

  1. type of care pathway

    Time frame: from cancer diagnosis during a year of follow-up

    The primary endpoint is the type of care pathway as identified by longitudinal clustering analysis of Electronic Health Record (EHR) data in the year following diagnosis (medical diagnoses, procedures, admissions, treatment received),.

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Collaborators

  • CentraleSupelec School of Engineering
  • Inria, the French National Institute for computer science and applied mathematics

Registry information

Acronym: PASSAGE

Important dates

Study start
2024
Primary completion
2028
Study completion
2028
First posted
Jul 30, 2025
Registry last updated
Jul 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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