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Completed

NCT Number: NCT05787353

Cardiopulmonary Rehabilitation for Post-acute COVID-19 Symptoms

The purpose of this RETROSPECTIVE study was to compare the effect of a hospital and home-based cardiopulmonary rehabilitation (CPR) program on exercise endurance and quality of life in post-acute COVID-19 patients.

88 post-acute COVID-19 patients were divided two groups according to receiving hospital (n=45) or home-based CPR (n=43)in our rehabilitation clinic between January and July 2021. Both protocols consisted of aerobic, breathing and flexibility exercises. Hospital-based CPR: three or four days per week for a total of 20 sessions. Home-based CPR: three or four days/a week over a period of six weeks. The results of six meters walk test (6MWT) for exercise endurance as a main outcome measure, and Borg-dyspnea/fatigue, the visual analog scale (VAS) for pain and the Short Form-36 (SF-36) as secondary outcome measures before and after treatment were recorded.

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Key information

Conditions

Cardiopulmonary

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Eskişehir Osmangazi University

Eskişehir, Odunpazarı, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • being 18 years or older
  • having COVID-19 treatment (home quarantine/hospital/intensive care unit) according to a positive polymerase chain reaction (PCR) test in a nasopharyngeal + oropharyngeal swab or chest computed tomography (CT)
  • participating in a home-based exercise program (for 6 weeks) or hospital-based CPR (for 12-20 sessions) due to post-acute COVID-19 symptoms (fatigue, myalgia, dyspnea).

Exclusion criteria

  • Patients who had both a negative PCR test and chest CT
  • Patients who had not completed the six minute walk test (6MWT), Borg scales, Short Form-36 and Visual analog scale-pain.
  • Acute COVID-19 patients (patients whose symptoms had started less than one month previous)

Treatment and study plan

Exercise programme

Other

Both protocols consisted of aerobic, breathing and flexibility exercises. Hospital-based CPR: three or four days per week for a total of 20 sessions. Home-based CPR: three or four days/a week over a period of six weeks.

Primary outcomes

  1. Exercise endurance

    Time frame: One day before exercise programme start and one day later exercise programme ends

    Six minutes walk test (All patients walked along a 30-meter-long corridor without obstacles at their normal walking speed, how many meters they walked was noted.)

Secondary outcomes

  1. Dyspnea

    Time frame: One day before exercise programme start and one day later exercise programme ends

    Borg scale were also measured before and after 6MWT for perceived dyspnea (scale range from 0 to 10)

  2. Muscle fatigue

    Time frame: One day before exercise programme start and one day later exercise programme ends

    Borg muscle fatigue (scale range from 6 to 20: higher values show more severe symptoms)

  3. short form 36

    Time frame: One day before exercise programme start and one day later exercise programme ends

    A quality-of-life assessment was performed using the Short Form-36, which has 36 items regarding physical function, physical role, emotional role, energy, body pain, mental health, general health, and social function. The scale ranges from 0 (poor health) to 100 (perfect health)

  4. Musculoskeletal Pain

    Time frame: One day before exercise programme start and one day later exercise programme ends

    Visual analog scale-pain was used to measure general body musculoskeletal pain, which was assessed from 0 (no pain) to 10 (worst possible pain)

Sponsors and collaborators

Lead sponsor

Eskisehir City Hospital

Other

Registry information

Official study title

Hospital- Versus Home-based Cardiopulmonary Rehabilitation for Post-acute COVID-19 Symptoms

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Mar 28, 2023
Registry last updated
Mar 30, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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