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NCT Number: NCT06780514

Cardiopulmonary Exercise Testing in Girls (8-18y) with Turner Sydrome.

The goal of this clinical trial is to have a beter insight in the exercise tolerance in girls with Turner Syndrome aged 8-18 years . The main question it aims to answer is:

Is there a difference in VO2 max comparing Turner syndrome girls with standard values? How do cardiovascular parameters change during exercise (heart rate, bloodpressure, ...)

Participants will perform a cyclo-ergometry in a standardised way.

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Key information

Conditions

Turner Syndrome Cardiovascular Abnormalities Cardiovascular Diseases Chromosome Disorders Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Disorders of Sex Development Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genetic Diseases, Inborn Gonadal Disorders Gonadal Dysgenesis Heart Defects, Congenital Heart Diseases Male Urogenital Diseases Sex Chromosome Disorders Sex Chromosome Disorders of Sex Development Urogenital Abnormalities Urogenital Diseases

Age range

8 year–18 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Ghent University Hospital

Ghent, 9000, Belgium

Location status: Recruiting

Location contact

Bauke Debo

CONTACT

093329813

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Turner syndrome girls aged 8-18 years old

Exclusion criteria

  • Severe mental impairement making it impossible to perform an exercise test

Treatment and study plan

cardiopulmonary exercise test

Diagnostic Test

To our knowledge, this is the first study to perform CPET's in Turner Girls aged <18 years

Other names: CPET, cyclo-ergometry

Primary outcomes

  1. VO2 max

    Time frame: Whitin a week after the CPET

    VO2 max is the maximum volume (V) of oxygen (O2) your body can process during exercise

Secondary outcomes

  1. Bloodpressure

    Time frame: Whitin a week after the CPET

  2. Heart rate

    Time frame: Whitin a week after the CPET

Study contacts

Contact information is provided by the study sponsor or research team.

Dr. Debo

CONTACT

[email protected]

093329813

Sponsors and collaborators

Lead sponsor

University Hospital, Ghent

Other

Registry information

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Jan 17, 2025
Registry last updated
Jan 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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