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Completed

NCT Number: NCT04163848

CARbon Impact of aNesthesic Gas

Assessing the impact of anesthesia practice on global warming and carbon footprint becomes part of the standard of care and is growing concern within the anesthesia community. Global Warming Potential (GWP) is a measure of how much a given mass of greenhouse gas contributes to global warming over a specified time period. Inhaled anesthetics have various GWP20: 349 for sevoflurane and 3714 for desflurane. However, GWP20 and CDE20 alone are not sufficient to evaluate the environmental impact of anesthetic gases. Other parameters must be included in the analysis: fresh gas flow (FGF), carrier gas (air, O2, N2O) and potency of the anesthetic gas. Unfortunately, the majority of trials did not fully consider the FGF reduction and the fact that desflurane can be administered with new closed or very low-flow anesthesia circuits as opposed as the recommended 2L/min that must be used for sevoflurane according to its monography in Canada. Most of the calculations were made on a purely theoretical approach that could be different from actual measurements based on a strictly monitored anesthesia practice. When continuous and accurate gas monitoring and analysis is used as recommended nowadays, the use of closed or semi-closed-circuit anesthesia with very low FGF might allow for a reduction of more than 80% of the anesthetic gas administration and its consequent pollution. By properly monitoring the anesthesia depth and analgesia adequacy, the investigators can reduce the gas consumption. The proposed study will aim at determining whether with the help of high-quality monitoring (BIS and NOL) and high-end ventilators that allow minimal fresh gas flow, the use of desflurane remains more polluting than sevoflurane.

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA 1-3 patients,
  • laparoscopic general, gynecological or urologic surgery requiring general anesthesia without additional regional anesthesia technique
  • fully consented,
  • BMI < 40,
  • age > 18yo,

Exclusion criteria

  • post-operative need for a neuraxial or regional analgesic technique
  • history of active coronary artery disease
  • serious cardiac arrhythmia (including atrial fibrillation)
  • history of substance abuse
  • chronic use of psychotropic and/or opioid drugs
  • history of psychiatric diseases with the need of medication
  • history of refractory PONV
  • allergy or contra-indication to any drug used in the study protocol
  • refusal of the patient for participation in the study

Treatment and study plan

Pollution

Other

CO2 equivalent productions related to anesthetic gases use during general anesthesia for laparoscopic surgery

Primary outcomes

  1. CO2 equivalent of volatile inhaled anesthesic gases use in grams

    Time frame: From intubation to end of surgery

    To compare total volatile inhaled anesthetics consumption in CO2 equivalent (grams) per hour during anesthesia for laparoscopic surgery between two groups: Group "D" for Desflurane and group "S" for Sevoflurane

Secondary outcomes

  1. Total volatile inhalated anesthesics consumption in mL

    Time frame: From intubation to end of surgery

    To compare the total volatile inhaled anesthetics consumption in mL, mL/h and mL/kg/h during anesthesia for laparoscopic surgery between desflurane and sevoflurane

  2. Cost in dollars

    Time frame: From intubation to end of surgery

    To compare the total cost of volatile inhalated anesthesics (mL of gaz x $/mL of gaz) for each group

  3. Extubation time in minutes

    Time frame: From stopping anesthesics gases to extubation

    To compare the extubation time

  4. Recovery room time in minutes

    Time frame: From end of surgery to 240minutes post-surgery

    To compare the time spent in the recovery room

Sponsors and collaborators

Lead sponsor

Ciusss de L'Est de l'Île de Montréal

Other

Registry information

Official study title

CARbon Impact of aNesthesic Gas - A Carbon Footprint Comparison of Sevoflurane and Desflurane in an Optimized Fresh Gas Flow Protocol

Acronym: CARING

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Nov 15, 2019
Registry last updated
Jan 27, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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