Carbachols Headache-inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients

The purpose of this study is to test if carbachol infusion induces headache in migraine subjects as well as intra- and extra-cerebral vasodilatation.

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Key information

Conditions

Headache Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Danish Headache Center

Glostrup Municipality, 2600, Denmark

About this study

To test if infusion of Carbachol induces headache in 12 migraine subjects as well as intra- and extra-cerebral vasodilatation in a double-blinded study

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Migraine without aura
Weight 50-100 kg

Exclusion criteria

Other significant diseases
Migraine 5 days prior to experiment

Treatment and study plan

Carbachol

Drug

3 microgram per kg bodyweight infused intravenously

Primary outcomes

Headache response after Carbachol infusion

Time frame: 1 day after infusion

Sponsors and collaborators

Lead sponsor

Danish Headache Center

Other

Registry information

Official study title

Experimental Study That Investigates the Effect of an Acetylcholine Analogue in Terms of Headache and Changes in Intra- and Extra-cerebral Vessels During and After Infusion of Carbachol

Important dates

Study start: 2007
Primary completion: 2008
Study completion: 2009
First posted: Nov 28, 2007
Registry last updated: Aug 3, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed