CAPACITY (Cardiac Amyloidosis and Physical ACtivITY) Study

The Atrium Health cardiac rehabilitation program delivers a comprehensive approach to improve cardiac performance including supervised exercise programs and has the ideal infrastructure to offer cardio-oncology rehabilitation (CORE) to all our cancer patients in the future. Currently neither CORE nor cardiac rehabilitation for HFpEF are covered by insurance, and hence the targeting of a higher risk cancer and non-cancer population of cardiac amyloidosis patients to objectively measure the benefits of a supervised exercise program ultimately to expand eligibility to all cancer patients and shape the treatment and payor landscape in the future.

Inclusion criteria

• Age > 18
• New York Heart Association (NYHA) Class I-III Heart Failure
• Able to Exercise
• On stable treatment for their cardiac amyloidosis or under active surveillance
• Life expectancy of at least 6 months
• Ability to understand and the willingness to sign a written informed consent document in English, and the willingness/ability to comply with the protocol activities
• Participant must be able and willing to follow the cardiac rehabilitation activities

Exclusion criteria

• Inability to provide informed consent
• Inability to commit to in-person supervised exercise sessions for three one-hour sessions a week for 12 weeks
• NYHA Class IV Heart Failure
• Pulmonary disease requiring home oxygen
• Gait instability or history of prior falls
• In the opinion of the Principal Investigator, have a clinically significant comorbid disease that is likely to affect the ability of the patient to complete the trial, interfere with their ability with measurement of self-reported outcomes.