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NCT Number: NCT07711548

Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?

So far, treatment with semaglutide (Wegovy) for therapy of obesity demonstrates substantial effects. However, most patients do not desire life-long pharmaceutical therapy or discontinue this treatment regime. This is accompanied by rapid weight regain. Moreover, numerous patients are open to an intermittent therapy.

This trial aims to investigate whether two diet interventions can keep weight stable after weight loss with semaglutide in people with obesity or overweight.

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Key information

Conditions

Obesity & Overweight Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Weight Loss Maintenance

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI ≥ 30 kg/m² OR ≥ 27 kg/m² with concomitant cardiometabolic risk factors (metabolic syndrome, elevated blood pressure, dyslipidemia or impaired glucose metabolism (but not type 2 diabetes)

Exclusion criteria

  • BMI ≥ 45 kg/m²
  • intake of glucose lowering drugs
  • presence of incretin-based treatment
  • acute severe CVD
  • uncontrolled hypertension
  • severe hepatic or renal diseases
  • severe food allergy or malabsorption disease
  • active cancer
  • condition after bariatric surgery
  • history of eating disorder
  • concurrent pregnancy and breastfeeding

Treatment and study plan

NutriAct plus

Behavioral

Dietary pattern, vegetarian version of the NutriAct pattern

Rescue VLCD

Behavioral

Very low calorie diet as full meal replacement over 28 days in case of weight regain

Primary outcomes

  1. weight in kg

    Time frame: body weight in kg after weight loss (3 to 5 months) and dietary intervention (12 months)

Sponsors and collaborators

Lead sponsor

Knut Mai

Other

Collaborators

  • Austrian Science Fund (FWF)
  • Czech Health Research Agency
  • DLR Project Management Agency (DLR)
  • Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)
  • ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK (ECRIN)
  • German Federal Ministry of Research, Technology, and Space (BMFTR)
  • Institute for Clinical and Experimental Medicine
  • Latvian Council of Science
  • Ministry of Health, Czech Republic
  • University of Latvia
  • University of Vienna

Registry information

Official study title

DIETary Strategies to stabiLize Incretin-based Weight Loss in Obesity Management

Acronym: DIET-SLIM

Important dates

Study start
2027
Primary completion
2030
Study completion
2030
First posted
Jul 17, 2026
Registry last updated
Jul 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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