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Enrolling by Invitation

NCT Number: NCT07568470

Can the Phoenix Sign be Elicited With D5W

To determine if the Phoenix sign can be reliably elicited with non-guided subcutaneous infiltration of D5W (5% Dextrose in Water) in patients with subclinical weakness of the extensor hallucis longus (EHL) muscle.

Enrolling by Invitation

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Key information

Conditions

Drop Foot Mononeuropathies Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Peroneal Neuropathies

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

US Neuropathy Centers

Marietta, Georgia, 30067, United States

About this study

  • To determine the prevalence of subclinical EHL weakness in a general clinical population
  • To measure the time course of strength changes following D5W infiltration
  • To identify potential predictive factors for positive response to treatment

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • subjects must have a weakness of dorsiflexion and specifically of the Extensor Hallucis Longus muscle
  • drop foot

Exclusion criteria

  • Trypanaphobia
  • allergy to D5W

Treatment and study plan

Infiltration of D5W

Drug

There is no other intervention.

Primary outcomes

  1. Changes in motor strength of dorsiflexion of the anterior and lateral compartments of the lower extremity

    Time frame: From enrollment to end of their treatment at 1 day

    Each subject will receive the infiltration and then be assessed for any changes in motor strength at 4 and 10 minutes after the injection.

  2. Presence of absence of increase in motor strength of the lower extremity in dorsiflexion

    Time frame: From enrollment to the end of the day

    Using manual motor testing the strength of the lower extremity in dorsiflexion will be evaluated with a score of 1-5 out of 5.

  3. Number of subjects that have increased dorsiflexion strength after D5W infiltration

    Time frame: Enrollment to end of clinic vist in 1 hour

    Subjects will be evaluated by manual motor testing of the patient before and after infiltration of D5W on a 1 to 5 out of 5 mother strength grading.

Sponsors and collaborators

Lead sponsor

US Neuropathy Centers

Other

Registry information

Official study title

Elicitation of the Phoenix Sign With Non-guided Subcutaneous D5W Infiltration

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
May 5, 2026
Registry last updated
May 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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