Calculator Predicts Early Mortality Post Hepatocellular Carcinoma Resection

Using the multicenter data, we developed and validated an individualized online calculator to predict early mortality after liver resection for hepatocellular carcinoma. The user-friendly tool with 6 preoperative predictors demonstrated excellent accuracy. The freely available calculator may help identify high-risk patients and reduce futile liver resection for hepatocellular carcinoma.

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Key information

Conditions

To Predict Early Post-hepatectomy Mortality for HCC Adenocarcinoma Carcinoma Carcinoma, Hepatocellular Digestive System Diseases Digestive System Neoplasms Liver Diseases Liver Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Beijing Tsinghua Changgung Hospital

Beijing, 102218, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults (age ≥18 years) who underwent curative-intent hepatectomy for newly diagnosed HCC.

HCC diagnosis was confirmed histopathologically.

Exclusion criteria

Patients undergoing emergency hepatectomy for tumor rupture, as well as individuals with recurrent HCC, and those with missing survival data or less than 90 days of follow-up were excluded.

Treatment and study plan

Primary outcomes

90-day death

Time frame: The period starts from the day of the hepatectomy surgery and extends up to the 90th day post-surgery.

90-day mortality after hepatectomy for HCC

Sponsors and collaborators

Lead sponsor

Beijing Tsinghua Chang Gung Hospital

Other

Collaborators

Eastern Hepatobiliary Surgery Hospital of Shanghai
First Affiliated Hospital of Harbin Medical University
Fuyang people's hospital
Liuyang People's Hospital
Mengchao Hepatobiliary Hospital
Pu'er People's Hospital
Qianfoshan Hospital
The First Hospital of Jilin University
The Fourth Affiliated Hospital of Harbin Medical University
Ziyang First People's Hospital

Registry information

Official study title

Multi-institutional Development and Validation of an Individualized Online Calculator for Early Mortality Risk After Hepatectomy Among Patients With Hepatocellular Carcinoma

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2024
First posted: Oct 1, 2024
Registry last updated: Oct 1, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed