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NCT Number: NCT05928364

Buccal Mucosal Graft for Onlay Ureteroplasty in the Management of Proximal Ureteral Stricture

Onlay uretroplasty with either grafts or flaps has been attempted by many reconstructive urologists, ln particular buccal mucosa graft (BMG) ureteroplasty has been reported by many centers and has shown its feasibility and safety

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Key information

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Urology department - AlAzhar university

Cairo, Egypt

Location status: Recruiting

Location contact

Mohamed F Salman, MD

CONTACT

[email protected]

+201111788996

Mohamed F Salman, MD

PRINCIPAL_INVESTIGATOR

About this study

In cases of long segment upper ureteral stricture, more advanced surgical techniques, such as renal mobilization and downward nephropexy, ileal ureter replacement, transureteroureterostomy, and autotransplantation of the kidney, are necessary to provide a tension-free anastomosis.

Autotransplantation of the kidney needs more efforts, more experts and may lead to significant renovascular complications.

Also, there is severe metabolic and intestinal complications are associated with using of long intestinal segment in the management of ureteral stricture [9].

These previous side effects and difficulties make the management of long upper and middle ureteral strictures more complicated and indicate other lines of management urgently.

Even the ureteral stricture still not patent enough to drain urine but still, we can use it as a ureteral plate with little affection of its vascularity. Based on this theory an onlay repair technique was emerged.

Onlay uretroplasty with either grafts or flaps has been attempted by many reconstructive urologists, ln particular buccal mucosa graft (BMG) ureteroplasty has been reported by many centers and has shown its feasibility and safety.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Proximal ureteral stricture or uretropelvic junction obstruction (UPJO) which are not amenable for primery anastmosis.

Exclusion criteria

  • Buccal graft contraindications as i. Active oral infections ii.Oral cancers like cancers of lips, tongue or cheeks.

Treatment and study plan

Buccal mucosa for proximal ureter stricture

Procedure

Patients with inclusion criteria of uretral stricture will be treated with open uretroplasty with buccal graft and omental wrapping

Primary outcomes

  1. Restoration of ureteric patency.

    Time frame: 6 months post-operative

    Restoration of ureteric patency as assessed by contrast study (intravenous urography) and ureteroscope.

Secondary outcomes

  1. Pain relief after surgery

    Time frame: 6 months post-operative

    Relief of pain measured by Visual Analog Score for pain

Study contacts

Contact information is provided by the study sponsor or research team.

Mohamed F Salman, MD

CONTACT

[email protected]

+201111788996

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Jul 3, 2023
Registry last updated
Aug 15, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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