Bronchoalveolar Immune Response Determination

The purpose of this study is to establish if cells present in lung tissue during extrinsic allergic alveolitis (EAA) are able to elicit an immune response against specific antigens. The hypothesis is: cells in BAL lavage fluid from patients with EAA will be responsive to specific antigens and this response can be measured using ELISPOT.

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Key information

Conditions

Extrinsic Allergic Alveolitis Alveolitis, Extrinsic Allergic Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Interstitial Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Diakonessenhuis Utrecht

Utrecht, 3582 KE, Netherlands

About this study

Subjects suffering from extrinsic allergic alveolitis caused by pigeons will undergo a broncho alveolar lavage. Cells obtained from this BAL will be used for ELISPOT technique with pigeon specific antigens

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

suspicion of pigeon induced extrinsic alveolitis

Exclusion criteria

use of oral steroids
unable to give informed consent
age below 18

Treatment and study plan

Primary outcomes

ELISPOT response in cells obtained from broncho-alveolar lavage

Time frame: 2 days

All elispots will be performed the same day, the end point will be available the next day

Secondary outcomes

Elispot response in cells from blood

Time frame: 2 days

ELispots will be performed the same day as blood collection, results will be available the next day

Sponsors and collaborators

Lead sponsor

Bossink, A.W.J.

Indiv

Registry information

Official study title

Study to Determine the Immune Response From Broncho-alveolar Cells Against Pigeon Specific Antigens

Acronym: BIRD

Important dates

Study start: 2011
Primary completion: 2012
Study completion: 2012
First posted: Nov 9, 2010
Registry last updated: Jan 19, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed