Study of Nasal Mucosa Histopathological Changes in Chronic Hypersensitivity Pneumonitis

Background:Hypersensitivity pneumonitis (HP) is an interstitial lung disease that develops after inhalation of organic or inorganic antigens in susceptible individuals. The nasal mucosa is constantly exposed to these antigens that can irritate the respiratory mucosa.

Objectives: to assess the burden of sinonasal symptoms in HP patients and to evaluate the nasal histopathology in those patients.

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Key information

Conditions

Hypersensitivity Pneumonitis Alveolitis, Extrinsic Allergic Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Interstitial Nasal Mucosal Disorder Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

29 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kasr alainy school of medicine

Cairo, 11562, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

all patients with clinical and radiological features of HP

Exclusion criteria

respiratory failure
patients on anticoagulants

Treatment and study plan

nasal endoscopy

Procedure

nasal endoscopy and mucosal biopsy

Primary outcomes

percentage of patients with HP developed nasal mucosa granuloma and lymphocytic infiltrations as detected by nasal endoscopy

Time frame: 6 months

nasal endoscopy and nasal mucosa biopsy was done for all patients to measure the % of patients with nasal granuloma and lymphocytic infiltrations

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Study of Nasal Mucosa Histopathological Changes in Patients With Chronic Hypersensitivity Pneumonitis

Important dates

Study start: 2021
Primary completion: 2022
Study completion: 2022
First posted: Feb 13, 2023
Registry last updated: Feb 13, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed