Skip to main content
OpenTrials
Completed

NCT Number: NCT02437448

Breath Analysis in Lung Fibrosis

The aim of the study is to answer the question whether a disease specific profile of breath in patients with idiopathic lung fibrosis can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Idiopathic Lung Fibrosis Idiopathic Pulmonary Fibrosis Lung Diseases Lung Diseases, Interstitial Pulmonary Fibrosis Respiratory Tract Diseases

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Pulmonary Division, University Hospital of Zurich

Zurich, 8091, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical symptoms consistent with IPF
  • Age 40 through 80 years
  • Diagnosis of UIP or IPF by HRCT and surgical lung biopsy as outlined in table 1. Only patients fulfilling the category "YES" will be included in the study.
  • Extent of fibrotic changes (honeycombing, reticular changes) greater than extent of emphysema on HRCT scan
  • No features supporting an alternative diagnosis

Exclusion criteria

  • Acute exacerbation within the last 6 weeks.
  • Any relevant lung disease other than pulmonary fibrosis.
  • Acute inflammatory disease (e.g. common cold) within the last 6 weeks.
  • Acute or chronic hepatic disease.
  • Renal failure or renal replacement therapy.

Treatment and study plan

No intervention

Other

Primary outcomes

  1. IPF-specific mass spectrometric profile of volatile organic compounds of exhaled breath analysis (markers of IPF in exhaled breath)

    Time frame: 1 day

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Collaborators

  • Swiss Federal Institute of Technology
  • Swiss National Science Foundation

Registry information

Official study title

Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry (SESI-MS) in Patients With Pulmonary Fibrosis

Important dates

Study start
2015
Primary completion
2018
Study completion
2018
First posted
May 7, 2015
Registry last updated
Oct 5, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.