Brain Perfusion in Pantothenate Kinase-associated Neurodegeneration (PKAN)

The purpose of this study is to learn whether blood flow in the brain is normal in people with pantothenate kinase-associated neurodegeneration (PKAN). Specifically, preliminary data suggest a region of the brain called the globus pallidus (GP), a key region affected by PKAN, may have reduced blood flow. Standard MRI and perfusion scanning techniques will be used to learn about cerebral blood flow in the globus pallidus and compare it to blood flow in other brain regions as well as to healthy controls.

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Key information

Conditions

Pantothenate Kinase-associated Neurodegeneration (PKAN) Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Heredodegenerative Disorders, Nervous System Movement Disorders Nervous System Diseases Neuroaxonal Dystrophies Neurodegenerative Diseases Pantothenate Kinase-Associated Neurodegeneration

Age range

7 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Oregon Health & Science University

Portland, Oregon, 97239, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

diagnosis of PKAN confirmed by MRI and gene testing
able to undergo MRI for approximately 1 hour without sedation

Exclusion criteria

deep brain stimulators or other conditions that warrant avoidance of a strong magnetic field
previous reaction to gadolinium (Gd) contrast agent
acute or chronic kidney dysfunction
pregnant and/or nursing at time of study

Treatment and study plan

Primary outcomes

ASL-derived cerebral blood flow(CBF)

Time frame: Single MRI

The unit of analyses will be the subject and the primary comparison will be the globus pallidus CBF between PKAN and healthy controls.

Sponsors and collaborators

Lead sponsor

Susan J. Hayflick

Other

Collaborators

Oregon Clinical and Translational Research Institute
Oregon Health and Science University

Registry information

Important dates

Study start: 2013
Primary completion: 2017
Study completion: 2018
First posted: Apr 23, 2013
Registry last updated: May 29, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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