Brain Oxygenation During Cardiopulmonary Resuscitation

The study is aimed to assess (a) the incidence of hyperoxia at the point of return of spontaneous circulation (ROSC) and (b) the role of arterial blood oxygen partial pressure to brain oxygenation during out-of-hospital cardiac arrest. 80 adult patients will be recruited in a physician staffed helicopter emergency medical services. Brain regional oxygen saturation and invasive blood pressure are monitored until hospital admission and arterial blood gases are analyzed immediately when the unit arrives to the patient and again at the time of ROSC.

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Key information

Conditions

Cardiac Arrest, Out-Of-Hospital Cardiovascular Diseases Heart Arrest Heart Diseases Out-of-Hospital Cardiac Arrest

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

FinnHEMS 10, Emergency Medicine and Services, Helsinki University Hospital

Vantaa, Finland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

out-of-hospital cardiac arrest of presumed cardiac origin
resuscitation will be continued at least 5 minutes (if return of spontaneous circulation not achieved earlier) after arrival of physician team

Exclusion criteria

do-not-attempt-resuscitation (DNAR) order or withdrawal of treatment by prehospital critical care physician
return of spontaneous circulation achieved before physician-led critical team arrives
external cause for cardiac arrest (e.g. trauma, suffocation)
workload too high or environment too dangerous to perform study procedures

Treatment and study plan

Standard cardiopulmonary resuscitation

Other

Standard Advanced Life Support based on guidelines 2015, including mechanical chest compression device

Primary outcomes

Arterial oxygen partial pressure

Time frame: 5-60 minutes

Arterial oxygen partial pressure at the time of return of spontaneous circulation (ROSC)

Secondary outcomes

Forehead regional oxygen saturation during resuscitation

Time frame: 0-60 minutes

Oxygen saturation measured using near-infrared spectroscopy

Sponsors and collaborators

Lead sponsor

Helsinki University Central Hospital

Other

Registry information

Official study title

Brain Oxygenation During Cardiopulmonary Resuscitation - Observational Pilot Study

Important dates

Study start: 2017
Primary completion: 2019
Study completion: 2019
First posted: Mar 13, 2018
Registry last updated: May 9, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed