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Completed

NCT Number: NCT00658216

Brain Natriuretic Peptide (BNP) Usefulness In Elderly Dyspneic Patients (BED)

The purpose of this study is to test the usefulness of measuring plasma brain natriuretic peptide (BNP) for diagnosis and prognosis in very elderly dyspneic patients.

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Key information

Conditions

Heart Failure Cardiovascular Diseases Disease Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

80 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Broca Hospital

Paris, 75013, France

About this study

Measurement of BNP concentration is approved for use in the diagnosis of heart failure (HF) in elderly patients below 80 years of age. The value of plasma BNP assays as diagnostic tools has not been determined in very elderly populations because the plasma BNP increases with age. This large, multicenter, prospective, observational, study in 300 participants is aimed to prospectively test the usefulness of measuring plasma BNP for diagnosis of HF in dyspneic patients aged 80 and older.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • acute dyspnea
  • crackles on lung auscultation,
  • hypoxemia,
  • right-sided signs.

Exclusion criteria

  • no exclusion criteria

Treatment and study plan

Primary outcomes

  1. Plasma BNP levels at T0 to test the optimal values of measuring plasma BNP for diagnosis of HF in patients older than 80 years.

    Time frame: 6 months

Secondary outcomes

  1. Plasma BNP levels at 3 times (T0, T48, Tend) to test the usefulness of measuring plasma BNP : 1.at T0 : in diagnosing HF using a 2-threshold up-and down-approach

    Time frame: 6 months

  2. 2.at T48 : in diagnosing and prognosing HF using a 2nd assay after 48 hours of treatment

    Time frame: 6 months

  3. 3.at Tend : in prognosing HF using a 3rd assay after the acute phase (composite criteria)

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Registry information

Official study title

Usefulness of Measuring Plasma Brain Natriuretic Peptide for Diagnosis and Prognosis in Very Elderly Patients.

Acronym: BED

Important dates

Study start
2007
Primary completion
2011
Study completion
2012
First posted
Apr 14, 2008
Registry last updated
Aug 5, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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