BNP Measurement Reduces Resource Utilization for Patients With CHF Admitted Thorough the ED

Measurement of brain natriuretic peptide (BNP) in dyspneic patients increases diagnostic accuracy for congestive heart failure (CHF). Limited information is available regarding economic outcomes attributable to BNP assay. The aim of this study was to assess the economic impact of BNP assay in elderly dyspneic patients presenting to the emergency department (ED).

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Key information

Conditions

Congestive Heart Failure Cardiovascular Diseases Heart Diseases Heart Failure

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Saint Marys Hospital, Mayo Clinic

Rochester, Minnesota, 55905, United States

About this study

Dyspneic patients 65 years were enrolled in a randomized, controlled trial; hemodynamically unstable patients were excluded. BNP (Biosite assay) levels were measured prior to physician assessment with randomization in 1:1 ratio to either BNP 1) level reported or 2) level not reported. ED physicians made triage decisions guided by clinical judgment and nomogram to aid in interpretation of BNP level. Primary outcome was mean total hospital cost per subject. Secondary outcomes included admission rate, service assignment, discharge diagnosis and length of stay. Differences between groups were compared by t-test with bootstrap. Costs reflect 2005 constant dollars.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Dyspneic patients 65 years or older presenting to the ED with chief complaint of shortness of breath.

Exclusion criteria

hemodynamically unstability

Treatment and study plan

Primary outcomes

Mean total hospital cost per subject

Time frame: spans from ED eval through hospitalization discharge

Secondary outcomes

Included admission rate, service assignment, discharge diagnosis, and length of stay.

Time frame: from ED evaluation through hospitalization discharge

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

BNP Measurement Reduces Resource Utilization for Patients With CHF Admitted Thorough the ED: A Clinical Development Project

Important dates

Study start: 2003
Primary completion: 2005
Study completion: 2005
First posted: Jan 8, 2008
Registry last updated: Jan 8, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed