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OpenTrials
Completed

NCT Number: NCT02389140

Blood Flow Within Active Myofascial Trigger Points Following Massage

The physiological response at the myofascial trigger point (MTrP) to massage is not known, yet would provide important objective evidence for a treatment effect and clarify the resolution process of a MTrP.

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Key information

Age range

21 year–49 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Colorado Hospital

Aurora, Colorado, 80045, United States

About this study

The physiological response at the myofascial trigger point (MTrP) to massage is not known, yet would provide important objective evidence for a treatment effect and clarify the resolution process of a MTrP. The long-term goal is to understand how therapeutic intervention affects the physiology of the MTrP. The objective of the proposed research is to assess, in a placebo controlled trial, the effectiveness of trigger point release massage (also known as ischemic compression) on blood flow at an active MTrP. The central hypothesis is that the contraction nodule of an active MTrP is characterized by an ischemic state comprised of reduced blood flow and subsequent dysregulation in carbohydrate metabolism. The investigators hypothesize that trigger point release (TPR) can positively impact blood flow leading to a change in high energy carbohydrate tension. The present study has been formulated, in part, from a preliminary study conducted by the investigators, which supports reduced blood flow and physiological disruption at active MTrPs. The proposed research will provide a physiological basis for massage to corroborate subjective reports of reduced pain sensitivity, impart credibility to treatment techniques, and provide insight into a mechanism of action for healing the MTrP.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chronic or episodic tension-type headache
  • active MTrP in upper trapezius
  • age 21-49
  • BMI between 18.5-24.9
  • either gender
  • any race or ethnicity

Exclusion criteria

  • No or latent MTrP in the upper trapezius
  • migraine 4+/month
  • cluster headache
  • fibromyalgia
  • neurological disease (e.g. Alzheimer's disease, Parkinson's disease, muscular dystrophy, multiple sclerosis)
  • cardiovascular disease (e.g. prior heart attack or stroke)
  • diabetes
  • pregnancy
  • a bleeding disorder (Self-report of hemophilia, known lack/deficiency of clotting factors, or presently °taking anti-coagulants (e.g. warfarin, Coumadin))
  • narcotic use
  • currently receiving massage
  • prior trigger point injection or needling therapies
  • allergy to lidocaine-type anesthetics such as lidocaine and prilocaine

Treatment and study plan

Trigger point release

Other

Trigger point therapy

ultrasound

Other

sham ultrasound

Primary outcomes

  1. Change in Blood Flow as measured by microdialysis

    Time frame: 1 hr pre intervention and 1 hr post intervention

Secondary outcomes

  1. Change in Glucose as measured by microdialysis

    Time frame: 1 hr pre intervention and 1 hr post intervention

  2. Change in Lactate as measured by microdialysis

    Time frame: 1 hr pre intervention and 1 hr post intervention

  3. Change in Pyruvate as measured by microdialysis

    Time frame: 1 hr pre intervention and 1 hr post intervention

Sponsors and collaborators

Lead sponsor

University of Colorado, Denver

Other

Registry information

Important dates

Study start
2015
Primary completion
2016
Study completion
2017
First posted
Mar 17, 2015
Registry last updated
Sep 1, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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