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Completed

NCT Number: NCT03169517

Blood Flow Index as an Indicator of Successful Peripheral Nerve Block

Laser speckle contrast imaging (LSCI) allows real-time, non-invasive, quantitative measurements of regional blood flow. The aim of this prospective observational study was to evaluate the blood flow changes by LSCI after peripheral nerve block and determine whether this novel optical technique can be used as a reliable indicator of successful blocks.

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Key information

Conditions

LASER

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Tongji Hospital

Wuhan, Hubei, China

About this study

Methods: One hundred adult patients scheduled for elective upper or lower limb surgery with peripheral nerve block will receive LSCI measurements and pinprick sensory tests before the block and at 5-min intervals till 30 min after the block. The sensitivity, specificity of LSCI as a diagnostic method will be determined by receiver operator characteristic analysis.

Clinical Implications: LSCI with quantitative data could be used as an indicator of successful blocks.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • informed consent
  • American Society of Anesthesiologists physical statusⅠ-Ⅱ
  • Undergo elective upper or lower limb surgery with peripheral nerve block

Exclusion criteria

  • refusal to participate in the study
  • peripheral vascular disease
  • digit injury or deficiency
  • colored or infected fingernails/toenails
  • BMI>35
  • those who had taken vasodilatory drugs before surgery
  • preoperative analgesic medications
  • Any contraindications to peripheral nerve block such as coagulation abnormalities, allergy to local anaesthetics, peripheral neuropathy.

Treatment and study plan

Primary outcomes

  1. diagnostic power of LSCI and pinprick sensory tests for predicting successful and failed blocks

    Time frame: at 5-min intervals till 30 min after regional block

    sensitivity and specificity

Secondary outcomes

  1. blood flow index

    Time frame: 5 min before regional block and at 5-min intervals till 30 min after regional block

    perfusion unit(PU)

Sponsors and collaborators

Lead sponsor

Huazhong University of Science and Technology

Other

Registry information

Official study title

Blood Flow Index as an Indicator of Successful Peripheral Nerve Block : A Prospective Observational Study Using Laser Speckle Contrast Imaging.

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
May 30, 2017
Registry last updated
Sep 6, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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