Bladder Bank (a Prospective Banking Study)

PRIMARY OBJECTIVE:

I. To establish a biobank of samples (blood and urine) to support the development of non-invasive tests for early detection of bladder cancer.

OUTLINE: This is an observational study.

Patients undergo blood and urine sample collection and have their medical records reviewed while on study.

Inclusion criteria

• Age > 18 years
• Patient has undergone office-based evaluation for hematuria [computed tomography (CT), ultrasound, cystoscopy]

Exclusion criteria

• Patient has known cancer outside of the target cancer 5 years prior to current collection (not including basal cell or squamous cell skin cancers; if patient has not been seen or if information is not available, the patient is eligible)
• Patient has recurrent muscle invasive bladder cancer
• Patient has ever been previously diagnosed with UTUC (upper tract urothelial carcinoma) prior to bladder resection
• Patient has received chemotherapy class drugs for the treatment of non-target origin cancer in the 5 years prior to current collection
• Patient has had any prior radiation therapy to the target lesion prior to current collection
• Patient has had a biopsy to the target organ and/or lesion within 3 days before collection
• Patient has undergone cystectomy or cystoprostatectomy
• Patient has transurethral instrumentation (placement of urinary catheter) within 7 days prior to urine collection
• Patient has had a urinary tract infection within 14 days prior to urine collection
• Patient has chronic indwelling urinary catheter