Skip to main content
OpenTrials
Completed

NCT Number: NCT01949623

Biomarkers In Retinitis Pigmentosa (BIRP)

In this study, markers of oxidative stress will be measured in the aqueous humour and plasma of RP patients compared to controls.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities Eye Diseases Eye Diseases, Hereditary Genetic Diseases, Inborn Retinal Degeneration Retinal Diseases Retinal Dystrophies

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Wilmer Eye Institute

Baltimore, Maryland, 21287, United States

About this study

People with Retinitis Pigmentosa have loss of night vision followed by loss of central vision due to damage and death of photoreceptors. One of the mechanisms causing damage is high levels of oxygen in the eye. This damage produces specific biomarkers which can be measured. In this study, these biomarkers will be assessed in people with Retinitis Pigmentosa and compared to controls.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Signed informed consent and authorization of use and disclosure of protected health information
  • Age more than or equal to 18 years
  • For the study group, patients diagnosed with Retinitis Pigmentosa by the investigators
  • For the control group, patients undergoing vitreoretinal surgery for macular hole, epiretinal membrane, vitreomacular traction, retinal detachment, neovascular Age-related Macular Degeneration (AMD) and Diabetic Retinopathy will be eligible

Exclusion criteria

  • Patients with active or suspected ocular or periocular infection

Treatment and study plan

Anterior Chamber (AC) tap

Other

Aqueous Samples will be collected for measurement of biomarkers

Primary outcomes

  1. Aqueous levels of markers of oxidative stress in patients with RP and controls.

    Time frame: 2 years

Sponsors and collaborators

Lead sponsor

Johns Hopkins University

Other

Registry information

Acronym: BIRP

Important dates

Study start
2013
Primary completion
2017
Study completion
2017
First posted
Sep 24, 2013
Registry last updated
Aug 16, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.