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NCT Number: NCT03676868

Biology of Cerebral Arteriovenous Malformations and Prognosis of Cerebral Arteriovenous Malformations

The cerebral arteriovenous malformations correspond to the formation of an entanglement of morphologically abnormal vessels called nidus, which shunt the blood circulation directly from the arterial circulation to the venous circulation.

The cerebral arteriovenous malformations are an important cause of hemorrhagic stroke.

The hypothesis is that cerebral haemorrhage associated with a cerebral arteriovenous malformations would come from peri-nidal micro-vessels, in connection with infiltration of leucocytes and / or defective maintenance of microvascular integrity by platelets.

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Key information

Conditions

Cerebral Arteriovenous Malformations Arteriovenous Malformations Brain Diseases Cardiovascular Abnormalities Cardiovascular Diseases Central Nervous System Diseases Central Nervous System Vascular Malformations Cerebrovascular Disorders Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Intracranial Arterial Diseases Intracranial Arteriovenous Malformations Nervous System Diseases Nervous System Malformations Rupture Ruptured or Unruptured Cerebral Arteriovenous Malformations Vascular Diseases Vascular Malformations Wounds and Injuries

Age range

0 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondation Ophtalmologique Rotschild

Paris, 75019, France

Location status: Recruiting

Location contact

Dr Jean-Philippe DESILLES

CONTACT

[email protected]

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient over 18 years old
  • Patient with a cerebral AVM for which an intervention (endovascular treatment or surgery) or only clinical monitoring
  • Express consent to participate in the study

And

  • children
  • Free informed and express consent of both holders of the minor patient's parental authority, or, by way of derogation and only if the other holder of parental authority cannot give his or her consent within a time limit compatible with the methodological requirements specific to the conduct of the research with regard to its purposes, of one of the two holders of parental authority

Exclusion criteria

  • Patient benefiting from a legal protection measure
  • Pregnant or breast feeding woman

Treatment and study plan

Primary outcomes

  1. Associaton between dosage of endothelial marker and the arteriovenous malformation pronostic

    Time frame: 6 months

    associaton between dosage of endothelial marker in blood samples and correlation with clinical outcome

  2. Associaton between dosage of platelet and the arteriovenous malformation pronostic

    Time frame: 6 months

    Dosage of platelet in blood samples and correlation with clinical outcome

  3. Associaton between dosage of neutrophilic and the arteriovenous malformation pronostic

    Time frame: 6 months

    Dosage of neutrophilic in blood samples and correlation with clinical outcome

  4. Associaton between neo-angiogenesis activation markers and the arteriovenous malformation pronostic

    Time frame: 6 months

    Dosage neo-angiogenesis activation markers in blood samples and correlation with clinical outcome

Study contacts

Contact information is provided by the study sponsor or research team.

Amélie Yavchitz

CONTACT

[email protected]

01 48 63 64 54 ext. +33

Jean Philippe DESILLES

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Official study title

Biology of Cerebral Arteriovenous Malformations : Study of the Link Between Blood Biomarkers and the Haemorrhagic Prognosis of Cerebral Arteriovenous Malformations

Acronym: BioMAV

Important dates

Study start
2018
Primary completion
2028
Study completion
2028
First posted
Sep 19, 2018
Registry last updated
Jun 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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