Biological Collection of the Rare Diseases of the Brain and Eye Vessels Cohort - 2

Inclusion criteria

For the group of patients with MVCR:

• Patients aged between 18 and 80 years at the time of inclusion
• Diagnosis confirmed by the detection of a pathogenic mutation in the NOTCH3 gene characteristic of CADASIL, or in another gene responsible for other forms of monogenic cSVD (such as the COL4A1, COL4A2 and HTRA1 genes) or a confirmed diagnosis of MOYA-MOYA (arteriography and/or genetic testing) or cavernoma, cerebral venous thrombosis or a cerebral vascular malformation, including cavernomas
• Covered by social security or an equivalent scheme
• Written consent.
• Patient included in the MVCR cohort For control group
• Subject aged between 18 and 80 at the time of inclusion.
• Written consent.
• Blood pressure < 140/90 mmHg without treatment or < 130/80 mmHg if treated and stable for ≥3 months
• Covered by social security or a similar scheme
• Strictly normal neurological examination (NIHSS=0; no focal deficit)
• Normal cognitive examination: MMSE ≥ 26

Exclusion criteria

Common exclusion criteria for patients and control subjects:

• A person referred to in Articles L. 1121-5 to L. 1121-8 and L. 1122-12 of the Public Health Code, defined as:

• Pregnant women, women in labour or breastfeeding women
• Persons deprived of their liberty by judicial or administrative decision
• Persons hospitalised without consent and not subject to a legal protection measure, and persons admitted to a health or social care facility for purposes other than research
• Minors
• Adults subject to a legal protection measure (guardianship, curatorship or judicial protection), adults unable to give consent and not subject to a legal protection measure
• Individuals subject to a withdrawal period for another research study
• Patients participating in another interventional research study
• Acute or chronic infectious disease

Specific exclusion criteria for control subjects

• Any identified extra- or intracranial vascular pathology requiring specific management
• Known cardiovascular disease (coronary artery disease, arterial disease, atrial fibrillation, heart failure)
• Neurological history: stroke, TIA, intracranial haemorrhage, meningitis/encephalitis, head injury with loss of consciousness >30 mins,
• Multiple sclerosis, neurodegenerative disease, active epilepsy,
• Current or former smoking (more than 10 pack-years)
• Diabetes
• Antithrombotic or lipid-lowering treatment