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Completed

NCT Number: NCT03680768

Biological Age in Health Promotion - Novel Health Technology

The purpose of this cross-sectional study is to collect relevant molecular markers of aging and measures of physiological function. Together these biomarkers are used to develope a new Biological Age model, useful in health promotion interventions in the public health sector .

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Key information

Conditions

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Copenhagen, Department of Biomedical Sciences

Copenhagen, 2200, Denmark

About this study

Study design: 100 participants representing the healthy danish working adult population. This study seek to include both men and women equally distributed in the range of 18-65 of age.

Data collection: After recruitment, participants need to attend once to the laboratory, overnight fasted and without having exercised for the previous 24 hours.

All analyse are done in investigators lab (Xlab) at the department of Biomedical Sciences, Copenhagen University. When analyzes are done, the results are used in algorithm developement in cooperation with Technical university Denmark.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Males and females interested in their personal health status
  • Healthy males and females

Exclusion criteria

  • Pregnancy
  • Previous or current cardiovascular disease
  • Use of medication that affects our measurements such as betablockers,statins or medication that affects the metabolism.

Treatment and study plan

Health Assessment

Other

The protocol includes measurements of body composition, strength test, functional and fitness test as well as biochemical measurements from blood samples and AGEreader

Primary outcomes

  1. Biological Age

    Time frame: Day 1

    A composite score of ones biological state (in years)

Secondary outcomes

  1. Fitness Level

    Time frame: Day 0

    VO2max - maximal oxygen consumption (ml/min/kg)

  2. Strength

    Time frame: Day 0

    Hand grip, isometric quadriceps and biceps strength (Nm)

  3. Sit to Stand test

    Time frame: Day 0

    Rise and sit from a chair as many times as possible during 1 minute (number og rises)

  4. Central obesity

    Time frame: Day 0

    Waist to hip ratio is measured by dividing waist circumference with hip circumference in cm.

  5. Weight

    Time frame: Day 0

    measured in kilograms

  6. Height

    Time frame: Day 0

    measured in cm

  7. Body composition

    Time frame: Day 0

    BMI (kg/m2) is calculated

  8. Muscle mass

    Time frame: Day 0

    muscle mass(g) is assessed by dual energy x-ray absorptiometry (DXA) and bioimpedance

  9. Fat mass

    Time frame: Day 0

    fat mass(g) is assessed by DXA and bioimpedance

  10. Fat percentage

    Time frame: Day 0

    Fat%, is assessed by DXA and bioimpedance

  11. Lipid profile

    Time frame: Day 0

    HighDensityLipoprotein (mmol/L), LowDensityLipoprofile (mmol/L), TriGlycerides (mmol/L), FreeFattyAcids (mmol/L) and Glycerol (mmol/L) is measured in a blood sample.

  12. Hormones

    Time frame: Day 0

    Sex hormones: testosteron and estradiol (nmol/L) and InsulinGrowthFactor-1 (nmol/L) and Insulin (µU/ml) ais analysed from blood samples

  13. Inflammatory profile

    Time frame: Day 0

    C-reactive protein mg/L, soluble urokinase plasminogen activating receptor ng/ml, InterLeukin 6,8 and 10 (pg/mL), tumor necrosis factor (pg/mL), Leptin and Adiponectin (ng/ml) is analysed from blood samples

  14. Levels of glycated protein and lipids as a result of exposure of excess sugars

    Time frame: Day 0

    advanced glycation endproducts (AGE) measured in the skin

  15. Color passport photography

    Time frame: Day 0

    Profile picture taken to assess perceived age

  16. Respirometry

    Time frame: Day 0

    forced vital capacity and forced expiratory volume at one second(L)

  17. Blood Pressure

    Time frame: Day 0

    Systolic and Diastolic blood pressure (mmHg)

  18. Blood glucose

    Time frame: Day 0

    HbA1c and fasting glucose (mmol/L) measured from blood sample

  19. Blood profile

    Time frame: Day 0

    Haematocrit and Haemoglobin (mmol/L) measured in a blood sample

  20. Aging biomarker

    Time frame: Day 0

    Chemokines Eotaxin (CCL11) analysed from blood samples

  21. Youth biomarker

    Time frame: Day 0

    Growth Differential Factor (GDF-11) analysed from blood samples

Sponsors and collaborators

Lead sponsor

University of Copenhagen

Other

Collaborators

  • Technical University of Denmark

Registry information

Official study title

Development of a New Biological Age Technology Applicable in Public Health Promotion Interventions.

Acronym: BATE

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Sep 21, 2018
Registry last updated
Feb 19, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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