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Completed

NCT Number: NCT01838759

Bioimpedance Spectroscopy for the Differential Diagnosis of Hyponatremia

We aimed to investigate the role of bioimpedance spectroscopy for the diagnosis of hyponatremia

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Key information

Conditions

Hyponatremia Edema Hypovolemia Metabolic Diseases Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms Water-Electrolyte Imbalance

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Bulent Ecevit University Hospital

Zonguldak, 67300, Turkey (Türkiye)

About this study

  • Up to now, "Hyponatremia" differentially diagnosed by physical examination, plasma and urine osmolalities, Echocardiography and biochemical measurements.
  • The purpose of this study is to determine whether bioimpedance spectroscopy can be used for the detection of hypovolemia and hypervolemia for the differential diagnosis of hyponatremia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Willing to participate in the study with written informed consent
  • Older than 18-years

Exclusion criteria

  • The presence of pacemaker or defibrillator
  • Artificial joints, pin or amputation
  • Pregnancy or lactating.

Treatment and study plan

Primary outcomes

  1. Accuracy of volume status measured by bioimpedance spectroscopy

    Time frame: Six months

    BIOIMPEDANCE SPECTROSCOPY:

    Overhydration (OH) measurement by Body Composition Monitor (Fresenius Medical Care)

    Negative values of "OH" indicating Hypovolemia and positive values for hypervolemia in hyponatremic patients.

Secondary outcomes

  1. Laboratory data and echocardiography

    Time frame: 6 Months

    LABORATORY MEASUREMENTS Hemoglobin, Hematocrit, White blood cell count Platelet count, Na, Potassium, Chlorur, Urea, Creatinine, Uric acid, Plasma osmolality, Urine osmolality, Alanine transaminase , Aspartate transaminase , Urine specific gravity,

    TREATMENT MODALITY

    • Diuretics
    • Intravenous hydration by isotonic saline

    ECHOCARDIOGRAPHY:

    Left ventricular end-diastolic diameter, Left ventricular end-systolic diameter, Ejection fraction(%), Left Atrium diameter, Aortic diameter, Right atrium diameter, Interventricular septum, Posterior wall thickness, Mitral insufficiency, Pulmonary insufficiency, Systolic pulmonary artery pressure, Tricuspid insufficiency

Sponsors and collaborators

Lead sponsor

Zonguldak Bulent Ecevit University

Other

Registry information

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Apr 24, 2013
Registry last updated
Nov 3, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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