University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
NCT Number: NCT05206266
Although multiple clinical trials have been reported studying the effects of turmeric and turmeric-derived curcuminoid containing extract on pain by various study designs (including both acute and chronic pain), with the most consistent positive pain reduction benefits at turmeric or curcuminoid levels above normal dietary intake estimates, studies assessing the combination of black pepper and turmeric at culinary relevant levels for pain remediation benefits are needed. As black pepper is reported to 'enhance' the effects of co-consumed compounds, we are testing whether consumption of black pepper alters the pain alleviating effects of turmeric when consumed at levels representative of potential dietary intakes.
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Notify Me40 year and older
All sexes
Interventional
Not applicable
Birmingham, Alabama, 35294, United States
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Three amounts of dietary turmeric will be tested: 1) turmeric 300 mg/day, 2) turmeric 1 g/day, 3) turmeric 3 g/day.
Three amounts of dietary turmeric (300mg/day, 1g/day or 3g/day) with black pepper (300 mg) added to the turmeric.
Time frame: 7 days
Self-reported pain according to Numeric Rating Scale (NRS), score from 0 = no pain, 10 = worst pain, within each 7-day intervention (placebo, turmeric, turmeric+black pepper)
Time frame: 7 days
Minutes of physical activity per week at moderate and vigorous intensity physical activity levels, and minutes of sedentary behavior, assessed via accelerometry
Time frame: Once per week during the 3 week (21-day) study
Time frame: Baseline and every 7 days during the 21-day study
(uU/ml)
Time frame: Baseline and every 7 days during the 21-day study
(ug/ml)
Time frame: Baseline and every 7 days during the 21-day study
Interleukin 6 (pg/ml)
Time frame: Baseline and every 7 days during the 21-day study
Interleukin 10 (pg/ml)
University of Alabama at Birmingham
Other
Bioenhancing Effects of Black Pepper With Turmeric on Pain Ratings: a Randomized, Clinical Trial
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