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Completed

NCT Number: NCT06624033

Bioavailability of Legume Proteins in Differents Products

The use of pea proteins could be interesting in specific foods. Indeed, these proteins could have great nutritional quality, with good amino acid profile. Therefore, the investigators study the bioavailability of protein and post-prandial variation of metabolic markers following consumption of pea protein-enriched products in healthy young subjects.

Main Objective is to compare plasma kinetics of leucine.

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Key information

Conditions

Healthy Congenital, Hereditary, and Neonatal Diseases and Abnormalities Endocrine Gland Neoplasms Endocrine System Diseases Genetic Diseases, Inborn Men Multiple Endocrine Neoplasia Multiple Endocrine Neoplasia Type 1 Neoplasms Neoplasms by Site Neoplasms, Multiple Primary Neoplastic Syndromes, Hereditary

Age range

18 year–29 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Centre de Recherche en Nutrition Clinique d'Auvergne

Clermont-Ferrand, Auvergne, 63009, France

About this study

The written agreement of the subjects will be obtained after information on the aims, nature and possible risks of the study.

Before inclusion, the volunteers will be subjected to a medical check-up at the Nutritional Exploration Unit which includes an examination of personal and family history and current drug treatments, as well as a standard medical examination and a blood test for a biological check-up. Compliance with the inclusion/ exclusion criteria will be verified during this review.

Volunteers included in the protocol will go to the Clinical Pharmacology Center (CPC) to perform the tests. At each visit, each volunteer will receive one of the six products.

The volunteer will be reviewed six times for the realization of a kinetics. First, three visits will be made with at least 7 days apart (wash out period). Then, after a 15-day break, three others visits will be organized spaced at least 7 days apart. The day before each visit, the evening meal will be standardized and eaten before 9 pm. A short catheter will be placed in a vein in the forearm for blood samples. After a fasting blood sample (T0), the subjects will consume one of the test meals. Nine samples will be then collected at several times after meal ingestion.

On these samples, plasma concentrations of amino acids, insulin, blood sugar, lipid balance and inflammatory markers will be measured. Any intercurrent events will be noted in the observation book. The test meal sequence will be randomly assigned to subjects (generating a random list) prior to the start of the study.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Major male volunteers under 30 (<30)
  • Body mass index between 22 and 28 kg/m²
  • Subjects considered healthy by investigator based on the examination, medical and clinical examination,
  • biological check up considered compatible with study participation
  • person who is in the position to sign informed consent

Exclusion criteria

  • Subject with a particular diet (vegetarians, vegans, nutritional supplements, etc.),
  • Subject weight < 60 kg
  • Subject refusing to consume one of the proposed products or the test meal
  • Subject with a food allergy(s) to one or more components of the study products (gluten, legumes, etc.), or with a contribution to the consumption of these products.
  • Subject with tumor pathology, inflammatory, moderate to severe kidney failure, malabsorption syndrome,
  • Subject being under drug treatment or dietary supplement that may influence the results of kinetics: treatments that may affect gastric emptying, intestinal absorption (smectite-based intestinal dressings, etc.), insulin and blood sugar, Oral nutritional supplements (NOC), proton pump inhibitors (PPIs), corticosteroids, nonsteroidal anti-inflammatory drugs, antibiotics for less than a month,
  • Subject with diabetes or dyslipidemia,
  • Subject with a heavy medical or surgical history that may pose a risk to the volunteer under the protocol,
  • Subject who has undergone surgery that may interfere with the objectives of the study (at the discretion of the investigating physician) within 3 months preceding the study,
  • Person refusing to be registered on the National File of Healthy Volunteers of the Ministry of Health,
  • Major subject under trusteeship or with limited rights,
  • Subject not affiliated with social security,
  • Subject during the exclusion period of a previous study (after verification in the Biomedical Research Volunteers File).

Treatment and study plan

amino acids kinetics

Other

After a fasting blood sample (T0), the subjects will consume one of the test meals. Nine samples will be then collected at several times after meal ingestion.

On these samples, plasma concentrations of amino acids, insulin, blood sugar, lipid balance and inflammatory markers will be measured.

Primary outcomes

  1. Changes in the plasma concentrations of leucinemia

    Time frame: 0 minute before the consumption of the test meals

    Maximum total plasma concentration of leucinemia measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point before (basal)

  2. Changes in the plasma concentrations of leucinemia

    Time frame: 15 minutes after ingestion

    Maximum total plasma concentration of leucinemia measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 15 minutes after the consumption of one of the 6 test periods.

  3. Changes in the plasma concentrations of leucinemia

    Time frame: 30 minutes after ingestion

    Maximum total plasma concentration of leucinemia measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 30 minutes after the consumption of one of the 6 test periods.

  4. Changes in the plasma concentrations of leucinemia

    Time frame: 60 minutes after ingestion

    Maximum total plasma concentration of leucinemia measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 60 minutes after the consumption of one of the 6 test periods.

  5. Changes in the plasma concentrations of leucinemia

    Time frame: 90 minutes after ingestion meals

    Maximum total plasma concentration of leucinemia measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 90 minutes after the consumption of one of the 6 test periods.

  6. Changes in the plasma concentrations of leucinemia

    Time frame: 120 minutes after ingestion

    Maximum total plasma concentration of leucinemia measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 120 minutes after the consumption of one of the 6 test periods.

  7. Changes in the plasma concentrations of leucinemia

    Time frame: 150 minutes after ingestion

    Maximum total plasma concentration of leucinemia measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 150 minutes after the consumption of one of the 6 test periods.

  8. Changes in the plasma concentrations of leucinemia

    Time frame: 180 minutes after ingestion

    Maximum total plasma concentration of leucinemia measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 180 minutes after the consumption of one of the 6 test periods.

  9. Changes in the plasma concentrations of leucinemia

    Time frame: 210 minutes after ingestion

    Maximum total plasma concentration of leucinemia measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 210 minutes after the consumption of one of the 6 test periods.

  10. Changes in the plasma concentrations of leucinemia

    Time frame: 240 minutes after ingestion

    Maximum total plasma concentration of leucinemia measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 240 minutes after the consumption of one of the 6 test periods.

  11. Changes in the plasma concentrations of leucinemia

    Time frame: 270 minutes after ingestion

    Maximum total plasma concentration of leucinemia measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 270 minutes after the consumption of one of the 6 test periods.

  12. Changes in the plasma concentrations of leucinemia

    Time frame: 300 minutes after ingestion

    Maximum total plasma concentration of leucinemia measured during different points of the 6 hours of the kinetics (one kinetic / type of product).One point at 300 minutes after the consumption of one of the 6 test periods.

  13. Changes in the plasma concentrations of leucinemia

    Time frame: 360 minutes after ingestion

    Maximum total plasma concentration of leucinemia measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 360 minutes after the consumption of one of the 6 test periods.

Secondary outcomes

  1. Changes in the plasma concentrations of the others amino acids

    Time frame: 0 minute before the consumption of the test meals,

    Maximum total plasma concentration of amino-acid measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point before (basal) the consumption of one of the 6 test periods.

  2. Changes in the plasma concentrations of the others amino acids

    Time frame: 15 minutes after ingestion

    Maximum total plasma concentration of amino-acid measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 15 minutes after the consumption of one of the 6 test periods.

  3. Changes in the plasma concentrations of the others amino acids

    Time frame: 30 minutes after ingestion

    Maximum total plasma concentration of amino-acid measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 30 minutes after the consumption of one of the 6 test periods.

  4. Changes in the plasma concentrations of the others amino acids

    Time frame: 45 minutes after ingestion

    Maximum total plasma concentration of amino-acid measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 45 minutes after the consumption of one of the 6 test periods.

  5. Changes in the plasma concentrations of the others amino acids

    Time frame: 60 minutes after ingestion

    Maximum total plasma concentration of amino-acid measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 60 minutes after the consumption of one of the 6 test periods.

  6. Changes in the plasma concentrations of the others amino acids

    Time frame: 90 minutes after ingestion

    Maximum total plasma concentration of amino-acid measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 90 minutes after the consumption of one of the 6 test periods.

  7. Changes in the plasma concentrations of the others amino acids

    Time frame: 120 minutes after ingestion

    Maximum total plasma concentration of amino-acid measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 120 minutes after the consumption of one of the 6 test periods.

  8. Changes in the plasma concentrations of the others amino acids

    Time frame: 180 minutes after ingestion

    Maximum total plasma concentration of amino-acid measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 180 minutes after the consumption of one of the 6 test periods.

  9. Changes in the plasma concentrations of the others amino acids

    Time frame: 210 minutes after ingestion

    Maximum total plasma concentration of amino-acid measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 210 minutes after the consumption of one of the 6 test periods.

  10. Changes in the plasma concentrations of the others amino acids

    Time frame: 240 minutes after ingestion

    Maximum total plasma concentration of amino-acid measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 240 minutes after the consumption of one of the 6 test periods.

  11. Changes in the plasma concentrations of the others amino acids

    Time frame: 270 minutes after ingestion

    Maximum total plasma concentration of amino-acid measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 270 minutes after the consumption of one of the 6 test periods.

  12. Changes in the plasma concentrations of the others amino acids

    Time frame: 300 minutes after ingestion

    Maximum total plasma concentration of amino-acid measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 300 minutes after the consumption of one of the 6 test periods.

  13. Changes in the plasma concentrations of the others amino acids

    Time frame: 360 minutes after ingestion

    Maximum total plasma concentration of amino-acid measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 360 minutes after the consumption of one of the 6 test periods.

  14. Changes of Blood sugar levels

    Time frame: 0 minute before the consumption of the test meals

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point before (basal) the consumption of one of the 6 test periods.

  15. Changes of Blood sugar levels

    Time frame: 15 minutes after ingestion

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 15 minutes after the consumption of one of the 6 test periods.

  16. Changes of Blood sugar levels

    Time frame: 30 minutes after ingestion

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 30 minutes after the consumption of one of the 6 test periods.

  17. Changes of Blood sugar levels

    Time frame: 45 minutes after ingestion

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 45 minutes after the consumption of one of the 6 test periods.

  18. Changes of Blood sugar levels

    Time frame: 60 minutes after ingestion

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 60 minutes after the consumption of one of the 6 test periods.

  19. Changes of Blood sugar levels

    Time frame: 90 minutes after ingestion

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 90 minutes after the consumption of one of the 6 test periods.

  20. Changes of Blood sugar levels

    Time frame: 120 minutes after ingestion

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 120 minutes after the consumption of one of the 6 test periods.

  21. Changes of Blood sugar levels

    Time frame: 150 minutes after ingestion

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 150 minutes after the consumption of one of the 6 test periods.

  22. Changes of Blood sugar levels

    Time frame: 180 minutes after ingestion

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 180 minutes after the consumption of one of the 6 test periods.

  23. Changes of Blood sugar levels

    Time frame: 210 minutes after ingestion

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 210 minutes after the consumption of one of the 6 test periods.

  24. Changes of Blood sugar levels

    Time frame: 240 minutes after ingestion

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 240 minutes after the consumption of one of the 6 test periods.

  25. Changes of Blood sugar levels

    Time frame: 270 minutes after ingestion

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 270 minutes after the consumption of one of the 6 test periods.

  26. Changes of Blood sugar levels

    Time frame: 300 minutes after ingestion

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 300 minutes after the consumption of one of the 6 test periods.

  27. Changes of Blood sugar levels

    Time frame: 360 minutes after ingestion

    Maximum total concentration of blood sugar measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 360 minutes after the consumption of one of the 6 test periods.

  28. Changes of insulin levels

    Time frame: 0 minute before the consumption of the test meals

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point before (basal) the consumption of one of the 6 test periods.

  29. Changes of insulin levels

    Time frame: 15 minutes after ingestion

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 15 minutes after the consumption of one of the 6 test periods.

  30. Changes of insulin levels

    Time frame: 30 minutes after ingestion

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 30 minutes after the consumption of one of the 6 test periods.

  31. Changes of insulin levels

    Time frame: 45 minutes after ingestion

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 45 minutes after the consumption of one of the 6 test periods.

  32. Changes of insulin levels

    Time frame: 60 minutes after ingestion

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 60 minutes after the consumption of one of the 6 test periods.

  33. Changes of insulin levels

    Time frame: 90 minutes after ingestion

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 90 minutes after the consumption of one of the 6 test periods.

  34. Changes of insulin levels

    Time frame: 120 minutes after ingestion

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 120 minutes after the consumption of one of the 6 test periods.

  35. Changes of insulin levels

    Time frame: 150 minutes after ingestion

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 150 minutes after the consumption of one of the 6 test periods.

  36. Changes of insulin levels

    Time frame: 180 minutes after ingestion

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 180 minutes after the consumption of one of the 6 test periods.

  37. Changes of insulin levels

    Time frame: 210 minutes after ingestion

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 210 minutes after the consumption of one of the 6 test periods.

  38. Changes of insulin levels

    Time frame: 240 minutes after ingestion

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 240 minutes after the consumption of one of the 6 test periods.

  39. Changes of insulin levels

    Time frame: 270 minutes after ingestion

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 270 minutes after the consumption of one of the 6 test periods.

  40. Changes of insulin levels

    Time frame: 300 minutes after ingestion

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 300 minutes after the consumption of one of the 6 test periods.

  41. Changes of insulin levels

    Time frame: 360 minutes after ingestion

    Maximum total concentration of insulin measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 360 minutes after the consumption of one of the 6 test periods.

  42. Changes lipid profile

    Time frame: 0 minute before the consumption of the test meals

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point before (basal) the consumption of one of the 6 test periods.

  43. Changes lipid profile

    Time frame: 15 minutes after ingestion

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 15 minutes after the consumption of one of the 6 test periods.

  44. Changes lipid profile

    Time frame: 30 minutes after ingestion

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 30 minutes after the consumption of one of the 6 test periods.

  45. Changes lipid profile

    Time frame: 45 minutes after ingestion

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 45 minutes after the consumption of one of the 6 test periods.

  46. Changes lipid profile

    Time frame: 60 minutes after ingestion

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 60 minutes after the consumption of one of the 6 test periods.

  47. Changes lipid profile

    Time frame: 90 minutes after ingestion

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 90 minutes after the consumption of one of the 6 test periods.

  48. Changes lipid profile

    Time frame: 120 minutes after ingestion

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 120 minutes after the consumption of one of the 6 test periods.

  49. Changes lipid profile

    Time frame: 150 minutes after ingestion

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 150 minutes after the consumption of one of the 6 test periods.

  50. Changes lipid profile

    Time frame: 180 minutes after ingestion

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 180 minutes after the consumption of one of the 6 test periods.

  51. Changes lipid profile

    Time frame: 210 minutes after ingestion

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 210 minutes after the consumption of one of the 6 test periods.

  52. Changes lipid profile

    Time frame: 240 minutes after ingestion

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 240 minutes after the consumption of one of the 6 test periods.

  53. Changes lipid profile

    Time frame: 270 minutes after ingestion

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 270 minutes after the consumption of one of the 6 test periods.

  54. Changes lipid profile

    Time frame: 300 minutes after ingestion

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 300 minutes after the consumption of one of the 6 test periods.

  55. Changes lipid profile

    Time frame: 360 minutes after ingestion

    Maximum total concentration of lipid profile measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 360 minutes after the consumption of one of the 6 test periods.

  56. Changes of pro-inflammatory cytokines (TNF α, IL-6 and IL-1β)

    Time frame: 0 minute before the consumption of the test meals

    Maximum total plasma concentration of of the pro-inflammatory cytokines measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point before (basal) the consumption of one of the 6 test periods.

  57. Changes of pro-inflammatory cytokines (TNF α, IL-6 and IL-1β)

    Time frame: 15 minutes after ingestion

    Maximum total plasma concentration of of the pro-inflammatory cytokines measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 15 minutes after the consumption of one of the 6 test periods.

  58. Changes of pro-inflammatory cytokines (TNF α, IL-6 and IL-1β)

    Time frame: 30 minutes after ingestion

    Maximum total plasma concentration of of the pro-inflammatory cytokines measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 30 minutes after the consumption of one of the 6 test periods.

  59. Changes of pro-inflammatory cytokines (TNF α, IL-6 and IL-1β)

    Time frame: 60 minutes after ingestion

    Maximum total plasma concentration of of the pro-inflammatory cytokines measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 60 minutes after the consumption of one of the 6 test periods.

  60. Changes of pro-inflammatory cytokines (TNF α, IL-6 and IL-1β)

    Time frame: 90 minutes after ingestion

    Maximum total plasma concentration of of the pro-inflammatory cytokines measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 90 minutes after the consumption of one of the 6 test periods.

  61. Changes of pro-inflammatory cytokines (TNF α, IL-6 and IL-1β)

    Time frame: 120 minutes after ingestion

    Maximum total plasma concentration of of the pro-inflammatory cytokines measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 120 minutes after the consumption of one of the 6 test periods.

  62. Changes of pro-inflammatory cytokines (TNF α, IL-6 and IL-1β)

    Time frame: 150 minutes after ingestion

    Maximum total plasma concentration of of the pro-inflammatory cytokines measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 150 minutes after the consumption of one of the 6 test periods.

  63. Changes of pro-inflammatory cytokines (TNF α, IL-6 and IL-1β)

    Time frame: 240 minutes after ingestion

    Maximum total plasma concentration of of the pro-inflammatory cytokines measured during different points of the 6 hours of the kinetics (one kinetic / type of product). One point at 240 minutes after the consumption of one of the 6 test periods.

  64. Areas under curves

    Time frame: 0 minute before the consumption of the test meals

    maximum concentration and time to reach this concentration will be compared between test meals

  65. Areas under curves

    Time frame: 15 minutes after ingestion

    maximum concentration and time to reach this concentration will be compared between test meals

  66. Areas under curves

    Time frame: 30 minutes after ingestion

    maximum concentration and time to reach this concentration will be compared between test meals

  67. Areas under curves

    Time frame: 60 minutes after ingestion

    maximum concentration and time to reach this concentration will be compared between test meals

  68. Areas under curves

    Time frame: 90 minutes after ingestion

    maximum concentration and time to reach this concentration will be compared between test meals

  69. Areas under curves

    Time frame: 120 minutes after ingestion

    maximum concentration and time to reach this concentration will be compared between test meals

  70. Areas under curves

    Time frame: 180 minutes after ingestion

    maximum concentration and time to reach this concentration will be compared between test meals

  71. Areas under curves

    Time frame: 240 minutes after ingestion

    maximum concentration and time to reach this concentration will be compared between test meals

  72. Areas under curves

    Time frame: 300 minutes after ingestion

    maximum concentration and time to reach this concentration will be compared between test meals

  73. Areas under curves

    Time frame: 360 minutes after ingestion

    maximum concentration and time to reach this concentration will be compared between test meals

Sponsors and collaborators

Lead sponsor

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Other

Collaborators

  • Centre de Recherche en Nutrition Humaine d'Auvergne

Registry information

Official study title

Single-blind, Randomized, Cross-over Comparative Bioavailability Study About the Kinetics of Plasma Amino Acid Concentrations Subsequent to the Consumption of Innovative Legume-based Products.

Acronym: LEG'UP

Important dates

Study start
2020
Primary completion
2022
Study completion
2023
First posted
Oct 2, 2024
Registry last updated
Oct 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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