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NCT Number: NCT03708627

Bimatoprost as a Treatment for Graves' Orbitopathy

Testing whether Bimatoprost, a topical eye drop used for glaucoma, can be used to induce periorbital fat atrophy in patients with Graves' disease

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Key information

Conditions

Graves Ophthalmopathy Autoimmune Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Endocrine System Diseases Exophthalmos Eye Diseases Eye Diseases, Hereditary Genetic Diseases, Inborn Goiter Graves Disease Hyperthyroidism Immune System Diseases Orbital Diseases Thyroid Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

University of Washington

Seattle, Washington, 98104, United States

Location status: Recruiting

Location contact

Alexandra Van Brummen, MD

CONTACT

[email protected]

206-543-7250

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Graves' Ophthalmopathy with Exophthalmos/Proptosis -

Exclusion criteria

Active Graves Disease, Currently pregnant, Taking Steroids

-

Treatment and study plan

Bimatoprost Ophthalmic

Drug

Bimatoprost, aka Lumigan, one drop in one eye nightly

Primary outcomes

  1. Reduction in periorbital fat causing improvement in proptosis

    Time frame: 1 year

Study contacts

Contact information is provided by the study sponsor or research team.

Emily Li, MD

CONTACT

[email protected]

410-955-1112

Sponsors and collaborators

Lead sponsor

Johns Hopkins University

Other

Registry information

Official study title

The Role of Bimatoprost in Graves' Periorbitopathy

Important dates

Study start
2017
Primary completion
2029
Study completion
2031
First posted
Oct 17, 2018
Registry last updated
Jul 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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