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Completed

NCT Number: NCT07496970

Bilateral Cervical Plexus Block for Postoperative Pain After Thyroidectomy

Patients undergoing thyroidectomy frequently experience moderate postoperative pain that may require opioid analgesics. Opioid use is associated with adverse effects such as nausea, vomiting, respiratory depression, and delayed recovery. Ultrasound-guided regional anesthesia techniques may provide effective postoperative analgesia while reducing opioid consumption.

The aim of this prospective randomized study was to evaluate the analgesic efficacy of ultrasound-guided bilateral superficial cervical plexus block (BSCPB) in patients undergoing thyroidectomy under general anesthesia. Patients were divided into two groups: a block group receiving BSCPB with 0.5% bupivacaine and a control group receiving general anesthesia alone. Postoperative pain scores, opioid consumption, intraoperative analgesic requirements, and postoperative complications were compared between the groups.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gaziantep University

Gaziantep, 27410, Turkey (Türkiye)

About this study

Postoperative pain is a common clinical problem following thyroidectomy and may negatively affect patient comfort, recovery, and overall surgical outcomes. Moderate postoperative pain is frequently observed after thyroid surgery, and inadequate pain control may lead to delayed mobilization, increased opioid consumption, and higher incidence of opioid-related adverse effects such as nausea, vomiting, respiratory depression, and sedation.

Regional anesthesia techniques have increasingly been used as part of multimodal analgesia strategies to improve postoperative pain control while reducing opioid requirements. The bilateral superficial cervical plexus block (BSCPB) is a regional anesthesia technique that can provide effective analgesia for surgical procedures involving the neck, including thyroidectomy, parathyroid surgery, and cervical lymph node excisions. When performed under ultrasound guidance, BSCPB allows accurate identification of anatomical structures and precise local anesthetic administration, which may improve block success and reduce potential complications.

The aim of this prospective study was to evaluate the analgesic efficacy of ultrasound-guided bilateral superficial cervical plexus block in patients undergoing thyroidectomy under general anesthesia.

A total of 40 patients aged between 18 and 65 years with American Society of Anesthesiologists (ASA) physical status I-III scheduled for elective thyroidectomy were included in the study. Patients were divided into two groups. In the block group (Group B), patients received ultrasound-guided bilateral superficial cervical plexus block using 10 ml of 0.5% bupivacaine on each side prior to surgery in addition to general anesthesia. In the control group (Group K), patients underwent thyroidectomy under general anesthesia without cervical plexus block.

Demographic characteristics, intraoperative hemodynamic parameters, anesthetic drug consumption, and intraoperative complications were recorded. Postoperative pain intensity was assessed using the Visual Analog Scale (VAS) and Numeric Rating Scale (NRS) at 0, 2, 6, 12, and 24 hours after surgery. Postoperative tramadol consumption within the first 24 hours was also recorded. Additionally, postoperative complications such as nausea, vomiting, and pruritus were evaluated.

The primary objective of the study was to compare postoperative pain scores between the two groups. Secondary outcomes included intraoperative remifentanil consumption, postoperative tramadol consumption, hemodynamic parameters, and postoperative complications.

The findings of this study aim to determine whether ultrasound-guided bilateral superficial cervical plexus block provides improved postoperative analgesia and reduces opioid requirements in patients undergoing thyroidectomy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age between 18 and 75 years American Society of Anesthesiologists (ASA) physical status I-III Scheduled for elective surgery under general anesthesia Ability to provide written informed consent

Exclusion criteria

Allergy to local anesthetic agents Coagulation disorders or anticoagulant use Infection at the injection site Severe cardiac, respiratory, hepatic, or renal disease Pregnancy or breastfeeding Inability to understand pain scoring systems (VAS/NRS)

Treatment and study plan

Ultrasound-Guided Bilateral Superficial Cervical Plexus Block

Procedure

Intervention Description:

Patients received an ultrasound-guided bilateral superficial cervical plexus block prior to surgery. A total of 20 ml of 0.5% bupivacaine (10 ml per side) was injected along the posterior border of the sternocleidomastoid muscle using the three-injection technique. The block was performed under ultrasound guidance before induction of general anesthesia to provide perioperative analgesia.

Standard General Anesthesia

Procedure

only general anesthesia

Primary outcomes

  1. Postoperative pain intensity (VAS)

    Time frame: Within the first 24 hours after surgery

    Postoperative pain assessed using the Visual Analog Scale (0-100 mm)

  2. Postoperative pain intensity (NRS)

    Time frame: Within the first 24 hours after surgery

    Description: Postoperative pain assessed using the Numeric Rating Scale (0-10)

Sponsors and collaborators

Lead sponsor

University of Gaziantep

Other

Registry information

Official study title

Evaluation of the Postoperative Analgesic Effect of Ultrasound-Guided Bilateral Superficial Cervical Plexus Block in Patients Undergoing Thyroidectomy Under General Anesthesia: A Prospective Randomized Controlled Study

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Mar 27, 2026
Registry last updated
Mar 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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