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Completed

NCT Number: NCT05371119

BFR in Overweight Sedentary Subjects

This project should allow the investigators to observe the effects of low load training under partial vascular occlusion (BFR) in comparison with resistance training at low load without partial vascular occlusion in sedentary people overweight on parameters : decrease in fat mass; increase in muscle mass 79; muscle strength; decrease in the energy cost of walking; increase in preferred walking speed; improvement in walking pattern in patients overweight. Training under partial vascular occlusion should facilitate physical activity in overweight people as it can be just as effective as a "classic" type training with heavy loads. Thus, this device could allow people for who wear heavy loads can present an obstacle to physical activity to feel more involved in the physical activity programs offered in medical or sports centers.

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Key information

Conditions

Overweight Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

ISSUL

Lausanne, Canton of Vaud, 1015, Switzerland

About this study

The main objective of this study is to observe the effects of low load training under vascular occlusion (BFR) compared with low load resistance training without vascular occlusion in overweight sedentary people on parameters such as: decrease in fat mass; lower blood sugar levels as well as lower blood triglycerides and cholesterol levels; increased muscle mass; muscle strength; the reduction of the energy cost of walking; increasing the preferred walking speed; improving the walking pattern in overweight patients.

3.2 Primary and secondary endpoints

The first hypothesis is that the BFR drive will be effective in improving walking economy (thus reducing the energy cost of walking) and increasing the preferred walking speed, by improving walking patterns.

The second hypothesis is that BFR training makes it possible to modify the body composition in a slight way and to promote the gain of muscle strength in overweight individuals who do not practice physical activity beforehand. In addition, blood tests will show a decrease in blood sugar, blood triglyceride levels and cholesterol.

3.3 Study design

This single-center project aims to test the effects of low-load training under partial vascular occlusion (BFR) compared to low-load resistance training without vascular occlusion in overweight sedentary people. The main expected effects are a decrease in fat mass, an increase in muscle mass and strength, a decrease in the energy cost of walking as well as an increase in preferential walking speed. This project is part of a continuity of research in a public health context in order to propose adapted and effective physical activity programs for an overweight population unable to train with heavy loads.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • IMC between 25 and 35
  • vaccin against Covid-19

Exclusion criteria

hypertension diabete

Treatment and study plan

Exercise intervention

Other

Training with light load with blood flow restriction (BFR)

Primary outcomes

  1. DEXA technology

    Time frame: One week before intervention

    Body composition assessment: relative lean and fat mass in all body segments

  2. DEXA technology

    Time frame: One week following the training intervention

    Body composition assessment: relative lean and fat mass in all body segments

  3. Evaluation of muscle strength from an isokinetic device

    Time frame: One week before intervention

    eccentric and concentric peak torque of the knee extensor muscles

  4. Evaluation of muscle strength from an isokinetic device

    Time frame: One week following the training intervention

    eccentric and concentric peak torque of the knee extensor muscles

  5. Evaluation of the preferential speed of walking in an ecological situation

    Time frame: One week before interventionn

    using of a treadmill with measurement of the ground reaction forces

  6. Evaluation of the preferential speed of walking in an ecological situation

    Time frame: One week following the training intervention

    using of a treadmill with measurement of the ground reaction forces

  7. Analysis of the biomechanics of walking on a treadmill instrumented with power platforms.

    Time frame: One week before intervention

    calculation of the mechanical work

  8. Analysis of the biomechanics of walking on a treadmill instrumented with power platforms.

    Time frame: One week following the training intervention

    calculation of the mechanical work

  9. Evaluation of the energy cost of walking

    Time frame: One week before intervention

    on a treadmill, by indirect calorimetry with gaz exchanges

  10. Evaluation of the energy cost of walking

    Time frame: One week following the training intervention

    on a treadmill, by indirect calorimetry with gaz exchanges

Sponsors and collaborators

Lead sponsor

University of Lausanne

Other

Registry information

Official study title

Effects of a Physical Activity Program With Partial Vascular Occlusion on Body Composition, Biomechanics and Walking Energy in Overweight Sedentary Subjects

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
May 12, 2022
Registry last updated
May 12, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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