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OpenTrials
Completed

NCT Number: NCT00906685

Bevacizumab for Central Retinal Vein Occlusion Study

Central retinal vein occlusion is a leading cause of severe visual impairment. Until now, no treatment has been available to improve visual acuity. The present study intends to investigate if intravitreal bevacizumab can improve visual acuity as compared to sham-treated control patients.

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Key information

Conditions

Central Retinal Vein Occlusion Cardiovascular Diseases Embolism and Thrombosis Eye Diseases Macular Degeneration Macular Edema Retinal Degeneration Retinal Diseases Retinal Vein Occlusion Thrombosis Vascular Diseases Venous Thrombosis

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

St Eriks Eye Hospital

Stockholm, 11282, Sweden

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • CRVO with duration < 6 months
  • Visual acuity of 20/800 to 20/50

Exclusion criteria

  • CRVO with duration of > 6 months
  • previous treatment with anti-angiogenic drugs

Treatment and study plan

Bevacizumab

Drug

Intravitreal injection of 1.25 mg bevacizumab

Sham bevacizumab injection

Drug

Sham intravitreal injection

Primary outcomes

  1. The proportion of patients gaining 15 ETDRS letters or more

    Time frame: 6 months

Secondary outcomes

  1. Change in foveal thickness

    Time frame: 6 months

  2. Cases of neovascular glaucoma

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Anders Kvanta

Other

Registry information

Official study title

A Prospective, Randomized, Controlled Study on Intravitreal Bevacizumab (Avastin) for Central Retinal Vein Occlusion (CRVO)

Important dates

Study start
2009
Primary completion
2011
Study completion
2011
First posted
May 21, 2009
Registry last updated
Nov 22, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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