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OpenTrials
Completed

NCT Number: NCT02192970

Bevacizumab Against Recurrent Retinal Detachment

The investigators hypothesize that bevacizumab instilled into the vitreous after primary retinal detachment surgery will reduce the formation of proliferative vitreoretinopathy and subsequent retinal re-detachment.

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Key information

Conditions

Retinal Detachment Eye Diseases Proliferative Vitreoretinopathy Retinal Diseases Vitreoretinopathy, Proliferative

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

University of Wisconsin

Madison, Wisconsin, 53705, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years
  • Eyes with rhegmatogenous retinal detachment

Exclusion criteria

  • Presence of PVR
  • Need for a procedure other than primary PPV such as a scleral buckle with or without PPV, laser retinopexy, or pneumatic retinopexy.
  • Recent intravitreal injection of an anti-VEGF agent less than 3 months prior
  • Secondary retinal detachment repair
  • Use of silicone oil as tamponade agent
  • Patients less than 18 years of age
  • Pregnancy
  • Known allergy or contraindication to intravitreal bevacizumab

Treatment and study plan

Bevacizumab

Drug

Other names: Avastin

Primary outcomes

  1. Number of Participants (or Chart Reviews) With Complete Success of Primary Vitrectomy Surgery

    Time frame: 6 months

    Complete success of primary vitrectomy surgery, defined as retinal re-attachment without the need for any additional surgical procedures.

Secondary outcomes

  1. Number of Participants (or Chart Reviews) With Presence of Proliferative Vitreoretinopathy

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

University of Wisconsin, Madison

Other

Registry information

Acronym: BEARRD

Important dates

Study start
2015
Primary completion
2019
Study completion
2019
First posted
Jul 17, 2014
Registry last updated
Mar 26, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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