Beta-CIT-SPECT and Neurophysiology in Depression

Aim of this project is to investigate the effects of escitalopram on monoamine transporter (SERT, DAT) availabilities as assessed by b-CIT and SPECT, and on neurophysiological parameters such as the loudness dependence of auditory evoked potentials (LDAEP) in patients with depression.

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Key information

Conditions

Depression Behavior Behavioral Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Depts. of Psychiatry and Nuclear Medicine, Ludwig-Maximilians-University of Munich

Munich, D-80336, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Psychiatric in or outpatients with acute depressive episode
Indication for pharmacological treatment

Exclusion criteria

Acute suicidality
Neurological or severe somatic disorders
Occupational exposition to radiation >15 mSv per year
Women during pregnancy or lactation

Treatment and study plan

β-CIT-SPECT, Neurophysiology

Procedure

β-CIT-SPECT scans and EEG recordings, two assessments each

Primary outcomes

changes in β-CIT/neurophysiological measurements from baseline to week 4

Time frame: two assessments, at baseline and week 4

Sponsors and collaborators

Lead sponsor

Ludwig-Maximilians - University of Munich

Other

Collaborators

H. Lundbeck A/S

Registry information

Official study title

Serotonin and Dopamine Transporter (SERT, DAT) Availabilities as Assessed by b-CIT and SPECT, and Neurophysiological Measures of Central Serotonergic Activity in Patients With Depression Under Treatment With Escitalopram

Important dates

Study start: 2005
Primary completion: 2009
Study completion: 2009
First posted: Sep 5, 2005
Registry last updated: Jun 2, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed