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Completed

NCT Number: NCT06062784

Bedside Tests of Cardiorespiratory Fitness

A study of 64 older adults over the age of 65y to assess the utility of patient characteristics and bedside measures of physical function and muscle size to predict cardiorespiratory fitness.

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Key information

Conditions

Aging

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre of Metabolism, Ageing and Physiology (COMAP), University of Nottingham

Derby, Derbyshire, DE22 3DT, United Kingdom

About this study

A study of 64 older adults over the age of 65y to assess the utility of patient characteristics (age, gender and BMI) and bedside measures of physical function (handgrip strength (HGS) and step box test) and muscle size (muscle thickness via B-mode ultrasonography (US)) to predict cardiorespiratory fitness (VO2peak and anaerobic threshold) as measured by the gold-standard assessment method, cardiopulmonary exercise testing (CPET).

Each participant will take part in a single assessment day (after health screening against CPET safety criteria) whereby they will have US measures of the vastus lateralis before completing HGS and step box test assessments, and finally a CPET.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Over 65y
  • Independent, community-dwelling

Exclusion criteria

  • Contraindications to CPET safety criteria

Treatment and study plan

Primary outcomes

  1. Cardiorespiratory fitness (CRF) - VO2 max

    Time frame: Single time-point - 8 to 12 minutes

    CRF via cardiopulmonary exercise testing (CPET). This includes a measure of maximum oxygen uptake (VO2 max) determined via inline breath gas analysis during an incremental cycle test.

  2. Cardiorespiratory fitness (CRF) - Anaerobic threshold

    Time frame: Single time-point - 8 to 12 minutes

    CRF via cardiopulmonary exercise testing (CPET). This includes a measure of anaerobic threshold (AT) determined via inline breath gas analysis during an incremental cycle test.

Secondary outcomes

  1. Muscle architecture - muscle thickness

    Time frame: Single time-point: 10 minutes

    Analysis of vastus lateralis muscle thickness using b-mode ultrasonography

  2. Muscle architecture - pennation angle

    Time frame: Single time-point: 10 minutes

    Analysis of vastus lateralis pennation angle using b-mode ultrasonography

  3. Muscle architecture - fascicle length

    Time frame: Single time-point: 10 minutes

    Analysis of vastus lateralis fascicle length using b-mode ultrasonography

Sponsors and collaborators

Lead sponsor

University of Nottingham

Other

Registry information

Official study title

Exploring the Utility of Bedside Tests for Predicting Cardiorespiratory Fitness in Older Adults

Important dates

Study start
2019
Primary completion
2021
Study completion
2021
First posted
Oct 2, 2023
Registry last updated
Sep 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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